يجب تسجيل الدخول أولا
The Relationship Between rs7903146C>T in TCF7L2 Gene and Type 2 Diabetes mellitus in Iraq Populations
| المصدر: | مجلة جامعة الحسين بن طلال للبحوث |
|---|---|
| الناشر: | جامعة الحسين بن طلال - عمادة البحث العلمي والدراسات العليا |
| المؤلف الرئيسي: | Al-Aridhi, Rasha Shakir Nima (Author) |
| مؤلفين آخرين: | Al Tufaili, Rasha Amer Noori (Co-Author) |
| المجلد/العدد: | مج5, ملحق |
| محكمة: | نعم |
| الدولة: |
الأردن |
| التاريخ الميلادي: |
2019
|
| الصفحات: | 16 - 26 |
| DOI: |
10.36621/0397-005-985-002 |
| ISSN: |
2519-7436 |
| رقم MD: | 1035803 |
| نوع المحتوى: | بحوث ومقالات |
| اللغة: | الإنجليزية |
| قواعد المعلومات: | EduSearch, AraBase, HumanIndex |
| مواضيع: | |
| كلمات المؤلف المفتاحية: |
TCF7L2 Gene and Type 2 Diabetes Mellitus
|
| رابط المحتوى: |
عدد مرات التحميل
3
| المستخلص: |
Background: Transcriptional factor 7-like 2 (TCF7L2) is a transcription factor in the Wnt-signaling pathway, expressed in many tissues including fat, liver and pancreatic islets of Langerhans. The relationship between TCF7L2 and type 2 diabetic mellitus (T2D) has been determined in several studies, but the data are dubious. Objective: the sole aim of this study is to determine the relationship between rs7903146C>T SNP in TCF7L2 gene with T2D in the Iraqi population. Methods: Two groups of Iraqi patients were recruited: 210 Type 2 Diabetic patients without complication and 210 aged-matched healthy subjects as the control group. The rs7903146C>T in TCF7L2 gene was detected using polymerase chain reaction-ARMS method. Results: The experimental results pointed out significant differences in the body mass index, west circumference, fasting blood glucose levels, HbA1c, triacylglycerol, very low density lipoprotein, high density lipoprotein cholesterol, total cholesterol, insulin, and HOMA-IR in T2D group with respect to control group. Interestingly we observed the frequency of homozygote mutant TT, heterozygote TC, and homozygote wild CC genotype of rs7903146C>T polymorphism in T2D group were 55.07%, 33.33%, and 11.59% respectively. Additionally, we identified a significant association between the SNP, haplotypes of HbA1C, fasting glucose, fasting insulin and HOMA-IR. We conclude that the variant rs7903146C>T in TCF7L2 gene is associated with T2D. Thus, this genetic test can be used to predict the occurrence of T2D in Iraqi population. |
|---|---|
| ISSN: |
2519-7436 |
عناصر مشابهة
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The association between rs7903146 polymorphism at the transcription factor 7-like 2 gene that regulates insulin and glucagon among type 2 diabetes mellitus patients
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بواسطة: النجار، محمود أحمد رشاد منشور: (2017) -
Molecular Characterization of Type 2 Diabetes Mellitus by Single Nucleotide Polymorphism of Transcription Factor7like 2 Gene
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