Phenotypic and Genotypic Screening for Metallobetalactamase Enzymes NDM and OXA51 Carbapenemases in Isolated Acinetobacter Baumannii from Tripoli Hospitals
| العنوان بلغة أخرى: |
المسح النوعي والجيني لإنزيمات الميتالوبيتا لاكتاميز NDM والكاربابينيميزOXA51 في عينات بكتيريا أسينيتوباكتر بوماني المعزوله من مستشفيات طرابلس |
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| المؤلف الرئيسي: | Abu Khutwa, Naseem Ali (Author) |
| مؤلفين آخرين: | Bashein, Abdulla (Advisor) , Sufya, Najib M. |
| محكمة: | نعم |
| التاريخ الميلادي: |
2018
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| موقع: | طرابلس |
| الصفحات: | 1 - 105 |
| رقم MD: | 1019388 |
| نوع المحتوى: | رسائل جامعية |
| اللغة: | الإنجليزية |
| الدرجة العلمية: | رسالة ماجستير |
| الجامعة: | جامعة طرابلس |
| الكلية: | كلية الصيدلة |
| الدولة: | ليبيا |
| قواعد المعلومات: | +Dissertations |
| مواضيع: | |
| رابط المحتوى: |
عدد مرات التحميل
16
| المستخلص: |
Acinetobacter baumannii is an opportunistic pathogen causing various nosocomial infections. The aim of this study was to characterize the molecular support of carbapenem-resistant A. baumannii clinical isolates recovered from four hospitals in Tripoli, Libya. A total of 119 A. baumannii isolates were characterized, overall the resistance prevalence was extremely high for aminoglycosides (79-96.6%), fluoroquinolones (94-96%), cephalosporins (96.6-100%) and carbapenemes (93.2-100%), all isolates were susceptible to colistin. In addition, 97.5% of isolates were identified as multidrug resistance (MDR). Varying degree of phenotypic detection of carbapenemes was determined; highest levels of carbapenemes were detected using chromogenic media (76.5%) compared with E-test (45.4%) and Modified Hodge Test (68.9%%) .The carbapeneme resistance-encoding genes detected were blaNDM (70.5%) and blaOXA51 (73.1%); the highest occurrence of blaNDM was demonstrated in Tripoli’s Central Hospital (5/5; 100%) then in Burn Plastic Surgery Hospital (42/57; 73.68%). The cooccurrence of these genes were demonstrated in (68/119; 57%) showing dissemination of carbapenemes resistance MDR A. baumannii in hospitals. This study shows that the high prevalence of blaNDM contribute to antibiotic resistance in Libyan hospitals and represents the high incidence of the association of these two carbapenemases in an autochthonous MDR A. baumannii isolated from patients in Libya, indicating that there is a longstanding infection control problem in these hospitals. |
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