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الرئيسية > Role of the Allelic Polymorphi...>الوصف

Role of the Allelic Polymorphisms of a Pleiotropic Cytokine (IL-6) as Genetic Factors in Iraqi Type 2 Diabetes Mellitus Patients

المصدر: مجلة جامعة الحسين بن طلال للبحوث
الناشر: جامعة الحسين بن طلال - عمادة البحث العلمي والدراسات العليا
المؤلف الرئيسي: Al-Husseini, Rand Muhammed A. Alhussein (Author)
مؤلفين آخرين: Hussein, Raed Ali (Co-Author)
المجلد/العدد: مج5, ملحق
محكمة: نعم
الدولة: الأردن
التاريخ الميلادي: 2019
الصفحات: 152 - 163
DOI: 10.36621/0397-005-985-013
ISSN: 2519-7436
رقم MD: 1035890
نوع المحتوى: بحوث ومقالات
اللغة: الإنجليزية
قواعد المعلومات: EduSearch, AraBase, HumanIndex
مواضيع:
السيتوكينات‬ | داء السكري من النوع 2 | النوكليوتيد المفرد
كلمات المؤلف المفتاحية:
Type 2 Diabetes Mellitus | Nucleotide Polymorphisms | IL-6 | Iraq
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المستخلص: Type 2 diabetes mellitus may happen under different causes, which may be detected by interactions between environment and genes. In this study we have explored the possible role of two single nucleotide polymorphisms in the 174 and 597 nucleotide positions at the promoter region of IL-6 gene as predictor for type 2 diabetes mellitus. The study population was included 120 Iraqi patients with type 2 diabetes mellitus. The distribution frequency of patients according to gender revealed that the higher rates of patients were in male than female with a significant difference (P<0.05) between them. The estimated prevalence of type 2 diabetes mellitus increased in the third age group (47-56 years) but without a significant difference in comparison with the other groups. The results of serum sugar, creatinine, urea, cholesterol, triglyceride, and LDL estimation were showed significantly (p<0.05) higher serum levels when compared to their ranges in the controls, while the serum HDL levels in patients were lower than in controls but without a significant difference. Finally, the present study had found that the genotype distribution among Iraqi patients with type 2 diabetes mellitus was either GG or GC in the region of promoter of IL-6 gene at the nucleotide in the 174 position ( 174G/C), with a significant difference between the allelic distribution of SNP in the regulatory promoter region of IL-6 gene of diabetic patients (GG: n= 101, 84.17%; GC: n=19, 15.83%; CC: n=0) and controls (GG: n= 49, 98%; GC: n=1, 2%; CC: n=0). The -597G/A single nucleotide polymorphism of IL-6 gene had no significant association with type 2 diabetes mellitus among Iraqi study population. That means the SNP in the regulatory promoter region of IL-6 gene (-174G/C) may plays role in the prediction and progression of type 2 diabetes mellitus among Iraqi study population.
ISSN: 2519-7436

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