Antiviral Activity of Extracted Fraction from Camel Urine Against the Middle East Respiratory Syndrome Corona and Influenza A (H1N1) Viruses
| المصدر: | مجلة الجمعية السعودية لدراسات الإبل |
|---|---|
| الناشر: | جامعة الملك سعود - الجمعية السعودية لدراسات الإبل |
| المؤلف الرئيسي: | Khorshid, Faten A. (Author) |
| مؤلفين آخرين: | Al Attas, Sanaa A. (Co-Author) , Kao, Moujahed (Co-Author) |
| المجلد/العدد: | ع1 |
| محكمة: | نعم |
| الدولة: |
السعودية |
| التاريخ الميلادي: |
2019
|
| التاريخ الهجري: | 1440 |
| الشهر: | إبريل |
| الصفحات: | 11 - 19 |
| رقم MD: | 1071033 |
| نوع المحتوى: | بحوث ومقالات |
| اللغة: | الإنجليزية |
| قواعد المعلومات: | HumanIndex |
| مواضيع: | |
| كلمات المؤلف المفتاحية: |
PMF | Mers | Co V | TGEV | H1N1 | Virostatic Activity
|
| رابط المحتوى: |
عدد مرات التحميل
17
| المستخلص: |
PMF, a camel urine fraction, is a traditional treatment of many human diseases. Demands for developing clinical treatments against dangerous viruses are increasing. This study aimed to investigate the effects of PMF as a novel pharmaceutical drug in vitro in inducing antiviral and/or virostatic activity against MERS-CoV and influenza A (H1N1) viruses. Infectivity assay was determined by end point dilution titration and infective dose was calculated and PMF veridical activity was evaluated as a reduction factor. Quantitative veridical suspension test was performed using TGEV virus, as a model for MERS-CoV, and H1N1 virus. The results indicated that PMF concentration of 20.34% inactivated the TGEV virus by 99.5% after 60 min, while 99.9% after 240 min. The results also indicated that the same PMF concentration inactivated H1N1 virus on Madin Darby canine kidney cells (MDCK/63) by 98.90% and 99.99% after 60 and 240 min, respectively. We speculate that copper and zinc elements in PMF might vitally contribute to the antiviral and virostatic activity. In conclusion, PMF was proven to induce antiviral in vitro activity against both viruses, hence, is recommended to use as a therapeutic antiviral agent in the future. |
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عناصر مشابهة
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بواسطة: Abdel Gader, Abdel Galil M. منشور: (2019)
