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الرئيسية > Evaluating the Severity of 6-H...>الوصف

Evaluating the Severity of 6-Hydroxydopamine Induced Parkinson’s Disease in Diabetic Rats

المؤلف الرئيسي: عبيد، هبة جابر صبحي (مؤلف)
مؤلفين آخرين: Abuirmeileh, Amjad (Advisor)
التاريخ الميلادي: 2020
موقع: عمان
الصفحات: 1 - 66
رقم MD: 1102868
نوع المحتوى: رسائل جامعية
اللغة: الإنجليزية
الدرجة العلمية: رسالة ماجستير
الجامعة: جامعة الاسراء الخاصة
الكلية: كلية الصيدلة
الدولة: الاردن
قواعد المعلومات: Dissertations
مواضيع:
مرض الباركنسون | داء السكري | الخلايا الدوبامينية
رابط المحتوى:
صفحة العنوان     
المستخلص     
قائمة المحتويات     
24 صفحة الأولى     

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المستخلص: Introduction: Parkinson’s disease and Diabetes Mellitus are both age related diseases. A debate related to the association between them started in the early sixties. Today, this possible link is still under study and of interest. Several studies described that the symptoms of Parkinson’s disease get worse after the onest of Diabetes Mellitus. Inflammation, mitochondrial dysfunction and oxidative stress are shared pathological mechanisms between neurodegenerative disorders (parkinson’s disease) and diabetes mellitus. Aim: The aim of this study is to understand the relationship between Parkinson’s disease and diabetes Mellitus. This may be achieved by examination the ability of 6- OHDA ,which is neurotoxic to damage dopaminergic neurons in presence of diabetes. Method: Male rats weighing between (220-250) were divided into four groups. Group A was a control and injected with vehicle only. Group B animals were given intraperitoneal streptozocin to induce diabetes. Group C was injected with intracerebral 6-OHDA alone and group D was subjected to 6-OHDA + streptozocin three days before surgery. The lesion severity was assessd neurochemically and behaviorally. Result: Fourteen days after intracerebral injection of 6-OHDA and after apomorphine rotation test, 6-OHDA lesioned rats that receive streptozocin showed significantly higher number of rotations in comparison to 6 OHDA alone group. Additionally, striatal dopamine concentration was lower in 6 OHDA+ streptozocin treated rats versus other groups. Conclusion: This work suggests that diabetes mellitus accelerate neurodegeneration and put subjects at high risk for Parkinson’

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