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الرئيسية > Effectiveness of Platelet Rich...>الوصف

Effectiveness of Platelet Rich Plasma on Regeneration of the Severed Achilles Tendon in Rabbit: Histopathological Evaluation

المصدر: مجلة سوهاج لشباب الباحثين
الناشر: جامعة سوهاج - كلية التربية
المؤلف الرئيسي: Salama, Mohamed M. A. (Author)
مؤلفين آخرين: El-Hawari, Sayed F. (Co-Author) , Elrashidy, Mohammed H. (Co-Author) , Abedellaa, Bahaa Eldeen A. (Co-Author)
المجلد/العدد: ع1
محكمة: نعم
الدولة: مصر
التاريخ الميلادي: 2021
الصفحات: 65 - 80
ISSN: 2735-5535
رقم MD: 1123705
نوع المحتوى: بحوث ومقالات
اللغة: الإنجليزية
قواعد المعلومات: EduSearch
مواضيع:
الأرانب | إصابات الأوتار | وتر العرقوب | الخلايا الليفية | الألياف الكولاجينية | البلازما الغنية بالصفائح الدموية
كلمات المؤلف المفتاحية:
Platelet-Rich Plasma "PRP" | Achilles Tendon Healing | Inflammation | Fibroblast | Angiogenesis | Collagen Fibers | Histopathological Evaluation
رابط المحتوى:
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المستخلص: Tendon injury is one of the most frequent, disabling acute orthopedic disorders and several techniques were used to restore the mobility of injured tendons, unfortunately, all of them had significant limitations. Platelets are considered a source of growth factors due to its alpha granules activity, so it is recently used to improve wound healing. The current experiment was designed to evaluate the effectiveness of platelet rich plasma on the healing of severed Achilles tendon and evaluating this process by histological examination and scoring. twenty-four apparently healthy adult female rabbits weighting 1.5 - 3 kg were equally and randomly allocated into two groups, group I: control group and group II: platelet rich plasma (PRP) treated group. Rabbits were kept one week for adaptation before the experimental operation. All animals were anaesthetized and the right pelvic limbs were prepared for aseptic surgery. Achilles tendons were transversely severed, the two tendon stumps were sutured then the subcutaneous tissue and skin were closed routinely. Following skin closure, the surgical limb was immobilized. PRP gel was applied as a smear to the surgically treated sites of rabbits in group II. The splint bandage and the skin stitches were removed 14 days postoperatively. At 2, 3, 6, and 12 weeks post operations, rabbits were euthanized, tendon tissue samples were collected and sent for histopathological examination. Our results revealed a significant less inflammation, more maturation of fibrocytes and more aggregation of collagen fibers in the tendon tissue treated with PRP in comparison with the control untreated groups. The approximation of normal tendinous tissue occured earlier in the PRP treated groups than in the control groups at the same experimental durations. The regeneration process was significantly improved by increasing the duration of treatment which showed complete curing after 12 weeks of PRP treatment. In conclusion, Administration of PRP gel shortened the inflammatory phase, increased collagen maturation, fibroblast number and promoted tendon healing in addition to reduction of surgical gap.
ISSN: 2735-5535

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