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Piptic Ulcer Disease and the Main Reason of this Disease

العنوان بلغة أخرى: المسبب الرئيسي لمرض قرحة المعدة
المصدر: مجلة أنوار المعرفة
الناشر: جامعة الزيتونة - كلية التربية - سوق الأحد
المؤلف الرئيسي: Erhoma, Fatma Elhade (Author)
مؤلفين آخرين: Alhmmali, Ezuideen Abdulmajid (Co-Author) , Alhaj, Abdulaziz Yousif (Co-Author)
المجلد/العدد: ع6
محكمة: نعم
الدولة: ليبيا
التاريخ الميلادي: 2019
الشهر: ديسمبر
الصفحات: 156 - 168
DOI: 10.35778/1753-000-006-011
رقم MD: 1263325
نوع المحتوى: بحوث ومقالات
اللغة: الإنجليزية
قواعد المعلومات: EduSearch, AraBase
مواضيع:
مرض القرحة الهضمية | أمراض المعدة | حساسية المضادات الحيوية
كلمات المؤلف المفتاحية:
Helicobacter Pylori | Peptic Ulcer Disease | Antibiotics Sensitivity Test
رابط المحتوى:
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المستخلص: Objective: To examine the effect of antibiotics (metronidazole, clarithromycin, amoxicillin, and tetracycline) on H. pylori isolated from patients with peptic ulcer disease admitting to the Center Hospital in Tripoli Libya Method: A total two hundred patients of 18-85 years (average 37 years) who had undergo an upper gastrointestinal endoscope (UGE). A total of 50 H. pylori isolates from stomach (antrum biopsy) by endoscopic biopsy, collected from treated and untreated patients, were tested for urease, catalase, oxidase and sensitivity test by disk diffusion test and agar dilution method. Also comparison between (males, females), and (treated, untreated) patients to antibiotic resistance rate. Result: The resistance rates were 8% for clarithromycin and 88% for metronidazole by disk diffusion test, (8%, 86%) for metronidazole and clarithromycin by agar dilution method. No isolates were resistant to amoxicillin or tetracycline. The females were more resistance to metronidazole than males (70.4% vs. 29.5%), respectively. The differences was statistically significant (P<0.05). Also the resistance rates to metronidazole was more in treated patients than untreated patient (61.3% vs. 36.6%) with a significant statistically difference (P<0.05). Conclusion : resistance of Helicobacter pylori to metronidazole is high among female patients, with tetracycline amoxicillin remaining the most efficient drugs. Furthermore Helicobacter pylori isolated from treated patients were found to be highly resistance to metronidazole than untreated patients.

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