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الرئيسية > Mechanism of Action of Liver G...>الوصف

Mechanism of Action of Liver Growth Induced by Nongenotoxic Carcinogens: Peroxisome Proliferators

المصدر: المجلة الجامعة
الناشر: جامعة الزاوية - مركز البحوث والدراسات العليا
المؤلف الرئيسي: Abushofa, Fikry A. (Author)
مؤلفين آخرين: Bell, David R. (Co-Author), Dyer, Paul S. (Co-Author)
المجلد/العدد: مج17, ع2
محكمة: نعم
الدولة: ليبيا
التاريخ الميلادي: 2015
الشهر: أغسطس
الصفحات: 73 - 91
رقم MD: 1263890
نوع المحتوى: بحوث ومقالات
اللغة: الإنجليزية
قواعد المعلومات: EduSearch, EcoLink, IslamicInfo, AraBase, HumanIndex
مواضيع:
سرطان الكبد | المواد المسرطنة | المواد الكيميائية
رابط المحتوى:

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المستخلص: The peroxisome proliferator activated receptor α (PPAR) is a member of the steroid/hormone receptor. Peroxisome proliferators cause non-genotoxic hepatocarcinogenesis in rodents. It is important to clarify the mechanism of action of the peroxisome proliferators in order to provide an assessment of the hazard, of such compounds to humans. It is also known that the peroxisome proliferators begin their actions by inducing hepatic DNA synthesis. Peroxisome proliferators (ciprofibrate) were investigated. Previous work had indicated that two successive doses of ciprofibrate treatment separated by 24hr, 48hr led to two rounds of liver cell replication, but it was not clear whether the same or different hepatocyte cells were involved in this growth response. To study this phenomenon, histochemical experimental work was undertaken to assess whether the same or different hepatocyte cells were stained during the two rounds of cell division following ciprofibrate treatment. The two histochemical stains used were EdU and BrdU, which are both base-pair analogues that stain nuclei undergoing DNA replication. It was hypothesized that if EdU was used to stain cells at 24 hr and then BrdU at 48 hr, that if the same cells were responding to ciprofibrate treatment then cells would be co-stained by both dyes, whereas if different cells were responding then there would be little or no double staining of hepatocyte cells– instead different cells would be stained. We found that different cells were stained by the two dyes, indicating that ciprofibrate treatment was targeting different cells.

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