Preparation of Some Gels Polymeric Networks Sustained Drug Prednisolone Anti-Inflammatory and Study as Slow Release (in Vivo) and (in Vitro)
| المصدر: | مجلة أبحاث ميسان |
|---|---|
| الناشر: | جامعة ميسان - كلية التربية |
| المؤلف الرئيسي: | Abdul Azeez, Mohammed R. (Author) |
| مؤلفين آخرين: | Al- Fartosy, Adnan J. M. (Co-Author), Hashim, Salah Sh. (Co-Author) |
| المجلد/العدد: | مج12, ع23 |
| محكمة: | نعم |
| الدولة: |
العراق |
| التاريخ الميلادي: |
2016
|
| الصفحات: | 15 - 29 |
| ISSN: |
6622-1815 |
| رقم MD: | 1287676 |
| نوع المحتوى: | بحوث ومقالات |
| اللغة: | الإنجليزية |
| قواعد المعلومات: | EduSearch |
| مواضيع: | |
| كلمات المؤلف المفتاحية: |
Drug Delivery | Anti-Inflammatory | Chitosan | Prednisolone
|
| رابط المحتوى: |
| المستخلص: |
Six were prepared polymer gel networks retina and retinal semi interference different proportions, namely: 1- (Starch-g-(PAA-CO-MBA)n P1 2- (Chitosan + Gluteraldehyd) P2 3- (Chitosan + sebacoylchloride) P3 4- (Chitosan +70% PEG + Gluteraldehyde) P4-4 5- (Chitosan +70%PEG+ Sebacoyl chloride) P5-4 6- (Starch-g-(PAA-CO-MBA)n+70% PEG) P6-4 The results showed that polymeric network effect (P5-4) loaded with a drug Prednisolone prevented constitute the updated material carrageenan and xylene, far behind the moral of the tumor (P < 0.05) at the time of 0.5, 1 hour, far behind the highly significant (P < 0.01) at the time of 2.4, 6, 8.10 The event lasted up to 23 hours from the start of the dosing time. When studying the effect of an anti-inflammatory chitosan it observed the emergence of significant differences (P < 0.05) after 0.5, 1, 2.4 & 6 an hour and a highly significant (P < 0.01) after the time of 8.10 & 23 hours from the time of dosing. As the drug Prednisolone unit led to obtain significant differences (P < 0.05) after 0.5 & 1 hour and a highly significant (P < 0.01) after 2 & 4 only an hour of the dosage time, then it observed decline in its influence as an anti-inflammatory, which runs to the end of the experimental period. |
|---|---|
| ISSN: |
6622-1815 |
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