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Association between IL-6 -174G/C Polymorphism and Unexplained Recurrent Abortion among Pregnant Ladies

المصدر: مجلة جامعة أم درمان الإسلامية
الناشر: جامعة أم درمان الإسلامية - معهد البحوث والدراسات الإستراتيجية
المؤلف الرئيسي: Elradi, Emtinan Elradi Ali (Author)
مؤلفين آخرين: Ali, Nour Mahmoud Abdelateif (Co-Author)
المجلد/العدد: مج19, ع2
محكمة: نعم
الدولة: السودان
التاريخ الميلادي: 2023
الشهر: يونيو
الصفحات: 179 - 184
ISSN: 1858-5361
رقم MD: 1482159
نوع المحتوى: بحوث ومقالات
اللغة: الإنجليزية
قواعد المعلومات: IslamicInfo
مواضيع:
كلمات المؤلف المفتاحية:
IL-6 | Polymorphism | RA | SSP-PCR
رابط المحتوى:
صورة الغلاف QR قانون
حفظ في:
المستخلص: Objective: The aim of this study was to determine the association between interleukin 6 (IL-6 -174G/ C) with susceptibility to Recurrent abortion (RA) in Sudanese pregnant ladies. Methods: case control study, the genetic polymorphism of IL-6 -174G/ C were studied by SSP- PCR in the DNA of a total of Forty (30) Sudanese ladies with the history of abortion and (30) ladies with normal pregnancy to three or more birth and without a previous abortion in the first trimester. Statistical analysis was performed using Chi square, correlation to spearman test to set differences were considered statistically significant with a p < 0.05. Results: CG genotyping prevalence were significantly higher in cases than in controls, P = 0.01, respectively. On the other hand, GG genotype prevalence were higher among control than in RM patients, P = 0.01, respectively. Conclusions: This study has proven a possible association of IL-6 −174 G/ C polymorphism with susceptibility recurrent abortions.

ISSN: 1858-5361

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