Evaluation the Salivary Anti-Porphyromonas Gingivalis "Iga and Igg" Response in Relation to Sera Levels of Ferritin and Vitamin D in Patients with Beta-Thalassemia Major
| المصدر: | مجلة ميسان للدراسات الأكاديمية |
|---|---|
| الناشر: | جامعة ميسان - كلية التربية الأساسية |
| المؤلف الرئيسي: | Abd, Shahad Fayiz (Author) |
| مؤلفين آخرين: | Mahmood, Maha Adel (Co-Author) |
| المجلد/العدد: | مج23, ع51 |
| محكمة: | نعم |
| الدولة: |
العراق |
| التاريخ الميلادي: |
2024
|
| الشهر: | أيلول |
| الصفحات: | 173 - 179 |
| DOI: |
10.54633/2333-023-051-015 |
| ISSN: |
1994-697X |
| رقم MD: | 1502940 |
| نوع المحتوى: | بحوث ومقالات |
| اللغة: | الإنجليزية |
| قواعد المعلومات: | EduSearch, HumanIndex |
| مواضيع: | |
| كلمات المؤلف المفتاحية: |
Beta-Thalassemia Major | Porphyromonas Gingivalis | Iron Overload | Ferritin | Vitamin D | Immune Response | Oral Health
|
| رابط المحتوى: |
عدد مرات التحميل
2
| المستخلص: |
Beta-thalassemia major is a severe hereditary anemia that necessitates regular blood transfusions, leading to iron overload. This condition also affects various biological markers, including ferritin and vitamin D levels, and can influence immune responses and oral health. The Aim of Study To examine the relationship between salivary Porphyromonas gingivalis IgA and IgG levels with the concentrations of ferritin and vitamin D in adolescent affected by Beta-Thalassemia Major. A case-control study was conducted from November 2023 to June 2024, involving 45 beta-thalassemia major adolescents and 45 healthy controls. All subjects were within ages ranged between 12-17 years. Saliva sample was collected and analyzed for estimation of salivary anti-Porphyromonas gingivalis IgA and IgG by using ELISA and blood collected and analyzed to measures s.ferritin and s.vitamin D by Cobas E411 system. The study group exhibited significantly lower mean salivary anti-Porphyromonas gingivalis IgA and IgG levels (40.59± 16.71 pg/ml), (15.23±3.21 pg/ml) compared to the control group (93.06± 55.25pg/ml), (18.92±3.32 pg/ml) (p=0.000) respectively. Serum ferritin (4158.37±542.64 ng/ml vs. 25.11±10.93 ng/ml), and vitamin D levels (9.83±4.69 ng/ml vs. 16.40±12.93 ng/ml) showed significant differences (p <0.05) between study and control groups. Beta-thalassemia major significantly impacts salivary and serum biochemical markers, highlighting the importance of regular monitoring and potential targeted therapies to manage iron overload and associated complications. The reduced immune response against Porphyromonas gingivalis in these patients suggests a need for enhanced oral health care and possibly prophylactic measures. |
|---|---|
| ISSN: |
1994-697X |
عناصر مشابهة
-
The Role of Hypoxia-Inducible Factor in Mediating Host Cell Responses to the Oral Pathogen Porphyromonas Gingivalis
بواسطة: Al Maghrabi, Sarah منشور: (2011) -
Lipopolysaccharide lipid A structural Heterogeneity of Porphyromonas gingivalis
بواسطة: Al Qutub, Montaser Nazmi منشور: (2005) -
Molecular Diagnosis of Beta Thalassemia Patients Using Mutations Detection and Hemoglobin Variants Analysis in Relation to the Level of Ferritin in Jordan
بواسطة: العويوي، منال محمد فهمي كريم منشور: (2021) -
Estimation of Lipid Profile and Ferritin of Beta-Thalassemia Patients in Tikrit City
بواسطة: Iada, Noor Faisal Nuaman منشور: (2013) -
Study of some Cellular Immune Responses of Cutaneous Leishmaniasis Patients with Evaluation of some Trace Metals in their Sera in Thamar-Yemen
بواسطة: الصابري، أروى علي مسعد منشور: (2014)
