The Relationship between Periodontitis Severity and MCP-1, IL-6 Levels in Gingival Crevicular Fluid
| المصدر: | مجلة ميسان للدراسات الأكاديمية |
|---|---|
| الناشر: | جامعة ميسان - كلية التربية الأساسية |
| المؤلف الرئيسي: | Ali, Mohammed Faisal (Author) |
| مؤلفين آخرين: | Taha, Ghada Ibrahim (Co-Author) |
| المجلد/العدد: | مج23, ع52 |
| محكمة: | نعم |
| الدولة: |
العراق |
| التاريخ الميلادي: |
2024
|
| الشهر: | كانون الأول |
| الصفحات: | 1 - 15 |
| DOI: |
10.54633/2333-023-052-001 |
| ISSN: |
1994-697X |
| رقم MD: | 1530740 |
| نوع المحتوى: | بحوث ومقالات |
| اللغة: | الإنجليزية |
| قواعد المعلومات: | EduSearch, HumanIndex |
| مواضيع: | |
| كلمات المؤلف المفتاحية: |
Periotron | Gingival Crevicular Fluid | Periodontitis | Monocyte Chemoattractant Protein-1 | Interleukin-6
|
| رابط المحتوى: |
عدد مرات التحميل
1
| المستخلص: |
Periodontitis is an inflammatory disorder that affects the teeth's supporting structures, leading to attachment loss and bone resorption. Cytokines produced by immune and non-immune cells regulate the immune response, acting as both pro-inflammatory and anti-inflammatory agents. This complex pathogenesis presents a significant public health challenge, emphasizing the need for early and accurate diagnostics. This study aimed to measure volume of gingival crevicular fluid (GCF) using Periotron® and assess potential biomarkers (MCP-1 and IL-6) to predict periodontal disease severity and progression using the Human Enzyme-linked immunosorbent Assay (ELISA). GCF samples were collected from 30 patients with stage 1 periodontitis, 30 patients with stage 3 periodontitis, and 30 healthy subjects. The level of GCF recorded using Periotron® was 0.04 μl for the healthy control group, 0.10 μl for the stage 1 periodontitis group, and 0.70 μl for the stage 3 periodontitis group. MCP-1 and IL-6 levels in the GCF were significantly higher in the stage 3 periodontitis group compared to the stage 1 periodontitis group and healthy subjects. |
|---|---|
| ISSN: |
1994-697X |
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