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This work composed of two parts, which are: Part One: Organic Synthesis 1. The Schiff bases compounds [1-5] were prepared by condensation reaction of gluteraldehyde with substituted anilines. This step replication between siccinic acid hydrazide with substituted aromatic aldehydes [7-11]. 2. The cycloaddition reaction of the Schiff base compounds [12-21] with maleic anhydride in the presence of absolute ethanol yielded 1, 3 – oxazepine compounds. This step replication with phthalic anhydride yielded 1, 3 – oxazepine compounds [22-31]. 3. Preparation of diazepine compounds [32-34] by condensation reaction of 2,3 – hydro –1,3 – oxazepine – 4,7 –dione with phenyl hydrazine and study the conformational analysis of the prepared compounds. 4. Preparation of azo – 1,3 – oxazepine by reacting diazonium salts derived from aniline with 1,3 – oxazepine compounds at (0-5)oC [38-43]. The structure of these new compounds were characterized by (Uv, IR) spectra and (H1-NMR) and (C13- NMR) spectra and elemental analysis (C,H,N) for some of the prepared compounds and followed by TLC (thin layer chromatography). Part Two: Biological evaluation The study also includes the biological activity for some of the prepared compounds against four kinds of germs which known by its resistance against antibiotics, these are (Staphilococcuiaureus) (positive for gram stain) and (Escherichia coli), (Pseudomonas aeruginosa) and (Kelbisalla pneumonia) (negative for gram stain)and studies the inhibition values for these compounds comparable with four of standard antibiotics as controls (Chloramphenicol, Neomycin, Ampecillin, Tetracycline) and the results show the ability of these prepared compounds to inhibit two kinds of germs it is (Pseudomonas aeruginosa) and (Staphilococcuiaureus) except (Kelbisalla pneumonia) and (Escherichia coli) comparable with control samples.
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