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الرئيسية > التقدير الطيفى للترايفلوبيرازي...>الوصف

التقدير الطيفى للترايفلوبيرازين والكلوربرومازين فى المستحضرات الصيدلانية باستخدام تفاعلات الاكسدة

العنوان بلغة أخرى: Spectrophotometric Determination Of Trifluoperazine Hydrochloride And Chlorpromazine Hydrochloride In Pharmaceutical Formulation By Oxidation Reactions
المؤلف الرئيسي: آل أبليش، عمر عدنان هاشم شريف (مؤلف)
مؤلفين آخرين: بكر، محسن حمزة (مشرف), خليل، علي إبراهيم (مشرف)
التاريخ الميلادي: 2012
موقع: تكريت
التاريخ الهجري: 1433
الصفحات: 1 - 92
رقم MD: 615718
نوع المحتوى: رسائل جامعية
اللغة: العربية
الدرجة العلمية: رسالة ماجستير
الجامعة: جامعة تكريت
الكلية: كلية التربية
الدولة: العراق
قواعد المعلومات: Dissertations
مواضيع:
الفينوثايازينات | الترايفلوبيرازين | الكلوربرومازين | المستحضرات الطبية | تفاعلات الاكسدة
رابط المحتوى:
صفحة العنوان     
المستخلص     
24 صفحة الأولى     

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المستخلص: Chapter one: contains introduction about drug compounds listed below - Trifluoperazine hydrochloride. - Methods for the determination of Trifluoperazine hydrochloride. - Chlorpromazine hydrochloride. - Methods for the determination of Chlorpromazine. - Aim of the research. Chapter two The Chapter includes the development of a new sensitive spectrophotometric method for the determination of a Trifluoperazine hydrochloride in aqueous solution. The method is based on the oxidative coupling reaction of Trifluoperazine hydrochloride with Sulphanilic acid reagent in a acidic medium pH 1.4 in the presence of Potassium Iodate to produce an intense violet coloured, water soluble and stable product , which exhibits maximum absorption at 544 nm. Beer’s law is obeyed over the arange 12 to 66 µg.ml-1 of Trifluoperazine hydrochloride, with a molar absorptivity of 4804 L.mo1-1 .cm -1 , Sandell’s sensitivity index of 0.01 µg.cm-2 , relative error range not more than 1.26% , and D.L 0.495 µg.ml-1 . The method has been successfully applied for the determination of Trifluoperazine hydrochloride in tablets.

Chapter three The Chapter includes the development of a sensitive spectrophotometric method for the determination of Trifluoperazine hydrochloride in aqueous solution based on reduction of Fe3+ with Trifluoperazine hydrochloride. The Fe2+ formed is complexed with 2,2’- bipyridyl at pH 4.2 to produce a red , water soluble and stable complex, which exhibits maximum absorption at 524 nm. Beer’s law obeyed in the concentration range from 2 to 50 µg.ml-1 of Trifluoperazine hydrochloride. The molar absorptivity is 5284.4 L.mol-1 .cm-1 and Sandell’s sensitivity index of 0.090 µg . cm-2 , relative error from 1.64 % , and D.L 0.788 µg.ml-1 . The method has been successfully applied to the determination of Trifluoperazine hydrochloride in tablets. Chapter Four The Chapter includes the development of a new sensitive spectrophotometric method for the determination of a Chlorpromazine hydrochloride in aqueous solution. The method is based on the oxidative coupling reaction of Chlorpromazine hydrochloride with Sulphanilamide reagent in a acidic medium pH 3.2 in the presence of Ammonium ceric Sulphate dihydrate to produce an intense violet coloured, water soluble and stable dye, which exhibits maximum absorption at 530 nm. Beer’s law is obeyed over the arange 6 to 66 µg.ml-1 of Chlorpromazine hydrochloride, with a molar absorptivity of 2842.28 L.mo1-1 .cm -1 , Sandell’s sensitivity index of 0.1250 µg.cm-2 , relative error range not more than 2.49 % , and D.L 1.2028 µg.ml-1 . The method has been successfully applied for the determination of Chlorpromazine hydrochloride in tablets.

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