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Picrotoxin "GABAA Receptor Antagonist" Shows a Protective Role in Brain Injury during Neonatal Development

المصدر: مجلة العلوم والدراسات الإنسانية
الناشر: جامعة بنغازي - كلية الآداب والعلوم بالمرج
المؤلف الرئيسي: Huria, Tahani (Author)
مؤلفين آخرين: Beeraka, Narasimha (Co-Author) , El Gradawi, Maha (Co-Author) , El Zewi, Samia (Co-Author)
المجلد/العدد: ع21
محكمة: نعم
الدولة: ليبيا
التاريخ الميلادي: 2016
الشهر: نوفمبر
الصفحات: 1 - 16
DOI: 10.37376/1571-000-021-006
ISSN: 2312-4962
رقم MD: 763432
نوع المحتوى: بحوث ومقالات
اللغة: الإنجليزية
قواعد المعلومات: HumanIndex
مواضيع:
الإصابات الدماغية | الفحوصات الطبية | حديثو الولادة
كلمات المؤلف المفتاحية:
Neonatal Brain | Ischaemia | Picrotoxin | Electrophysiology and Electron Microscopy
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المستخلص: GABAA-receptor antagonist picrotoxin has been shown to have actions upon brain injury during neonatal development. The significance of the expression of GABAA-receptors in developing brain specifically white matter during injury has not been completely examined. As well previous studies have concentrated upon brief periods of receptor activation and later points in development. For this paper work, the injury capacity of a standard 90-min period of both oxygen-glucose deprivation (OGD) and artificial cerebrospinal fluid (aCSF) coperfused with a GABAA-R antagonist were examined using electrophysiology and ultra-structural analysis techniques of P0 rat optic nerves (RONs) (a model of non-myelinated brain white matter). The result reveals the potential role of inhibitory other than excitatory neurotransmitters mediated injury in young brain in early points of development. It shows that GABAA-R block both increased compound action potential (CAP) under control conditions, and protected the RONs from OGD-induced injury. The protective effects of 100μM GABAA-R antagonist against OGD-induced axonal injury in P0-RONs using electrophysiological technique is consistent with ultra-micrograph data presented here showing protective effects against OGD-induced axonal and glial injury in P0-RONs. The results of both electrophysiology and microscopy are consistent with a potential role of GABAA-R-mediated injury in neonatal brain. This indicates the protective role of the GABAA-R antagonist against ischemic injury in non-myelinated brain.
ISSN: 2312-4962

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