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|3 10.26389/AJSRP.S27216
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| 041 |
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|a eng
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| 044 |
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|b فلسطين
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| 100 |
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|9 411171
|a Sultan, Mahmoud A.
|e Author
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| 245 |
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|a Effect of Antioxidants on the Occurrence of Pre-eclampsia in Women at Increased Risk
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| 260 |
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|b المركز القومي للبحوث بغزة
|c 2015
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| 300 |
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|a 35 - 40
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| 336 |
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|a بحوث ومقالات
|b Article
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| 520 |
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|b The objective of this work is: Asses the potential benefit of antioxidant supplementation on the occurrence of preeclampsia at high risk women. Patients and Methods: The number of primigravida women's collected was " 294" with gestational age ranged from 18-22 wks. .from (294) prim gravida cases ,(25) women were identified as being at increased risk of pre-eclampsia by abnormal Doppler wave form in either uterine artery at 18-22 weeks' gestation ( defined as a resistance index < 95th centile for gestation or the presence of an early diastolic notch ) , Another (25) women with history in the preceding pregnancy of pre-eclampsia, eclampsia or HELLP (Hemolysis, elevated liver enzymes, low platelets ) . -Total number of eligible participants were, (50) cases. Design and procedure: Cases divided randomly into two groups each 25 cases one group received tablets of 1000 mg vitamin C, (Cevitil efferecent. EPICO) + 400 iu of vitamin E (E-Viton 400 pharco). Venous blood for measurement of PAI-1 and PAI-2, The primary outcome measure was the ratio PAI-1 / PAI-2 and the secondary outcome prospectively according to guidelines of international society for the study of hypertension in pregnancy. Results: Doppler screening was done on, 294 prim gravidae with gestational age ranged from 18-22 weeks; only 42 women showed abnormal Doppler study so asked to come for rescanning at 24 weeks' gestation. 31 out of 42 patients (75%) have persistent abnormal study. The remainders of the 42 women (25%) were withdrawn from the study at 24 wks.' gestation because they have normal uterine-artery scan. Development of mild preeclampsia was statistically lower (p<0.5) in the study than that in the control group. However, development of sever preeclampsia or superimposed preeclampsia was statistically insignificant between both groups. PAI-1 was significantly increased in women developed preeclampsia more than normotensive (167±71.2, 113.8±35.6ng/ml respectively) with P=0.03 IN contrast PAI-2 was significantly decreased in women developed preeclampsia less than normotensive (105±34.9, 181.1±67.9ng/ml respectively) with P=0.018. Conclusion: Treatment and prevention trials of preeclampsia have been disappointing to date. However, this study has suggested causal links between oxidative stress and the development of preeclampsia indicate that may be a role for antioxidant vitamins in the prevention of preeclampsia. a high-risk population can be successfully identified on the basis of uterine-artery Doppler screening and pervious history of the disease.
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| 653 |
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|a النساء الحوامل
|a تسمم الحمل
|a مضادات الأكسدة
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| 700 |
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|9 411174
|a ElTamamy, E. A.
|e Co-Author
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| 700 |
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|9 411173
|a El Mesallawy, Y.
|e Co-Author
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| 700 |
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|9 411175
|a Arafa, Ibrahim
|e Co-Author
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| 700 |
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|9 411172
|a Salim, Hassan
|e Co-Author
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| 773 |
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|4 العلوم الإنسانية ، متعددة التخصصات
|4 العلوم الاجتماعية ، متعددة التخصصات
|6 Humanities, Multidisciplinary
|6 Social Sciences, Interdisciplinary
|c 004
|e Arab Journal of Sciences and Research Publishing
|f Al-Mağallaẗ al-ʿarabiyyaẗ li-l-ʿulūm wa-našr abḥāṯ
|l 001
|m مج1, ع1
|o 1564
|s المجلة العربية للعلوم ونشر الأبحاث
|v 001
|x 2518-5780
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| 856 |
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|u 1564-001-001-004.pdf
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| 930 |
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|d y
|p y
|q y
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| 995 |
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|a HumanIndex
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| 999 |
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|c 776780
|d 776780
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