The Role Of Solute Carrier Family 30 (Zinc Transporter), Member 8 "SLC30A8" Gene Polymorphism In Susceptibility To Type 2 Diabetes In Selected Sudanese Population
| المصدر: | مجلة الدراسات العليا |
|---|---|
| الناشر: | جامعة النيلين - كلية الدراسات العليا |
| المؤلف الرئيسي: | Ibrahim, Hadeel (Author) |
| مؤلفين آخرين: | Ibrahim, Amir (Co-Author) , Mohamed, Hiba Salah Aldin (Co-Author) , Salih, Mohammed (Co-Author) |
| المجلد/العدد: | مج2, ع5 |
| محكمة: | نعم |
| الدولة: |
السودان |
| التاريخ الميلادي: |
2014
|
| الصفحات: | 58 - 76 |
| ISSN: |
1858-6228 |
| رقم MD: | 790529 |
| نوع المحتوى: | بحوث ومقالات |
| قواعد المعلومات: | EcoLink, EduSearch, HumanIndex, IslamicInfo |
| مواضيع: | |
| رابط المحتوى: |
عدد مرات التحميل
10
| المستخلص: |
Back ground: SLC30A8 rs11558471 (26465A/G SLC30A8) is Single Nucleotide Polymorphism (SNP), which was found to be associated with Diabetes Type 2 in Han Chinese and European population and represents three other SNPS (rs3802177, rs13266634, rs11558471 ). Variation in SLC30A8 may affect zinc accumulation in insulin granules, affecting insulin stability, storage, or secretion. Higher total zinc intake may attenuate the glucose-raising effect of the rs11558471 SLC30A8 (zinc transporter) variant. Objective: To determine the role of 26465A/G SLC30A8 in susceptibility to T2D in selected Sudanese population. Research design and Methods: Pilot case control study was conducted to investigate the role of 26465A/G SLC30A8 in susceptibility to T2D. The target sequence was amplified using PCR with specific primers and the SNP was genotyped using RLFP (Pst1 restriction enzyme) in fifty five Type 2 Diabetic patients, and forty one normoglycaemic subjects from Tuti Island. Result: This SNP is in hardy Weinberg equilibrium (p=0.437). The major allele frequency in the T2D group and the control group was 0.934, and 0.9635 respectively. There was no significant association of this SNP with T2DM in the study population (chi square= 0.0696, P value= 0.404). Conclusion: The present study indicates that the polymorphism rs11558471 in the human SLC30A8 gene was not associated with type 2 diabetes. |
|---|---|
| ISSN: |
1858-6228 |
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