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02224nam a22002417a 4500 |
| 001 |
1587764 |
| 041 |
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|a eng
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| 044 |
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|b ليبيا
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| 100 |
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|a Abuhagr, Ali Moftah
|e Author
|9 444641
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| 245 |
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|a The Effect of Rheb Expression in Thoracic Muscle During the Molt Cycle in Gecarcinus Lateralis
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| 260 |
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|b الجامعة الأسمرية الإسلامية زليتن - كليتى الآداب والعلوم
|c 2015
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| 300 |
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|a 94 - 106
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| 336 |
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|a بحوث ومقالات
|b Article
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| 520 |
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|b This study aimed to detecte the role of Rheb in the molting cycle of Gecarcinus lateralis. Skeletal muscle atrophy in crustaceans is necessary for the progression of molting. The atrophy of thoracic muscles is coordinated by the action of ecdysteroid hormones. Thoracic muscle atrophy can occur during the intermolt period when hem lymph ecdysteroid levels are low. The insulin/mechanistic target of rapamycin (mTOR) pathway, previously shown to be important for growth, development, reproduction, and metamorphosis in insects, is a likely target of ecdysteroid regulation. As complete cDNAs for ras homolog enriched in brain (Rheb) the key activator of mTOR, have been cloned from Gecarcinus lateralis. Levels of Rheb increase dramatically during molting induced by either Eyestalk Ablation (ESA) or Multiple Limb Autotomy (MLA) and showed a correlation with levels of ecdysteroid in the thoracic muscle, in both molting paradigms. Our findiings indicate that Gl-Rheb is an important activator of crustacean mTOR signaling in the molt cycle in response to ecdysteroids
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| 653 |
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|a العضلات الصدرية
|a ضمور العضلات
|a التغيير الجينى
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| 692 |
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|b Rheb
|b Gene Expression
|b Crustacean
|b Ecdysteroid
|b Molting
|b MRNA
|b Thoracic Muscle
|b Eyestalk Ablation
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| 700 |
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|9 444643
|a Mykles, Donaldl
|e Co-Author
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| 700 |
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|9 444645
|a Chang, Ernest S.
|e Co-Author
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| 773 |
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|4 العلوم الإنسانية ، متعددة التخصصات
|6 Humanities, Multidisciplinary
|c 037
|l 027
|m ع27
|o 1582
|s مجلة العلوم الإنسانية والتطبيقية
|t Journal of Humanities and Applied Sciences
|v 000
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| 856 |
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|u 1582-000-027-037.pdf
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| 930 |
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|d y
|p y
|q n
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| 995 |
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|a HumanIndex
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| 999 |
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|c 829367
|d 829367
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