المستخلص: |
The present work deals with the reaction of 4-(4-Acetyl amino phenyl-4-oxobut-2-enoic acid (1) with hydrogen peroxide afforded oxirane derivative ( 2).The latter compound was treated with 2-amino – 5 – phenyl -1, 3, 4-thiadiazole to yield imidazole (3) .The new heterocyclic compounds( 4,5) are used as a key starting materials, reaction of (2) with amines, hydrazines, active methylene compounds and Friedel—Crafts reactions have been studied to synthesize some hetrocycles include derivatives. Also, (2) reacted with acetic acid. The structure of the newly synthesized compounds were elucidated by elemental analysis and spectroscopic data.
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