| المستخلص: |
Peganum and Erodium antimicrobial activity was used against Serratia spp., Bacillus cereus, E.coli, Micrococcus roseus, Staphylococcus aureus, Streptomyces spp. and Micrococcus lutaus. The method of extraction applied in this paper was the Soxhlet- hot extraction using petroleum ether and alcoholic solvents. The bacterial inhibition by the extract was as follows: Serratia spp was found moderately sensitive to Peganum harmala with failure to produce pigment. B. cereus was found moderately so to Peganum harmalal, while it showed low response to Peganum harmala. Escherchia coli showed moderate inhibition to Peganum harmala, Micrococcus roseus responded well to and grodium moderately to grodium. Staohylococcus aureus well to moderately to Peganum. Streptomyces spp. responded well only to based on the results obtained in this study, it can be concluded that using 50% acetone extract of, erodium glycophyllum has high antibacterial activity against pathogenic Staphylococcus aureus. Hot Soxhlet extraction method is recommended as well as 96 well treys microtitre plate method. The MIC of tested Erodium glycobhyllum against Ttaphyllococcus aureus was 25 and 50 mg/ml, respectively. Peganum showed moderate response to Eoridium Micrococcus luteaus showed height moderate response to Erodium, However the exception of Erodium in high concentration, none of the tested plants showed any signs of toxicity in rats tested. The former produced liver fatty changes and haemorrhages in the kidneys. Toxicity experiments of Erodium glycophyllum, and Peganum harmala using experimental animals (rats) confirm the safety of such plants for therapy of various diseases. An antibacterial evolution for the total extract of tested medicinal plants could also reveal a more potent activity toward tested pathogenic Gram positive and Gram negative bacteria. However, the plants differed significantly in the activity towards tested pathogenic bacteria. The differences could be attributed to their structural nature.
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