The Effect of Hypoxia on the Production of Matrix Metalloproteinase-7 Protein by Human Macrophages
| المصدر: | مجلة الأستاذ |
|---|---|
| الناشر: | جامعة طرابلس - نقابة أعضاء هيئة التدريس |
| المؤلف الرئيسي: | El barghati, Laila (Author) |
| مؤلفين آخرين: | Azzouz, Lubna (Co-Author) |
| المجلد/العدد: | ع10 |
| محكمة: | نعم |
| الدولة: |
ليبيا |
| التاريخ الميلادي: |
2016
|
| الشهر: | ربيع |
| الصفحات: | 4 - 16 |
| رقم MD: | 851130 |
| نوع المحتوى: | بحوث ومقالات |
| اللغة: | الإنجليزية |
| قواعد المعلومات: | EduSearch |
| مواضيع: | |
| كلمات المؤلف المفتاحية: |
Hypoxia | Matrix Metalloproteinase-7 | Macrophage | Tumorassociated Macrophages
|
| رابط المحتوى: |
| المستخلص: |
Macrophages have been shown to accumulate in hypoxic areas of solid tumors. These cells appear to undergo marked phenotypic changes and upregulate expression of a number of pro-tumor genes when exposed to hypoxia in vitro and in vivo as VEGF. Aim The aim of this study is to detect the release of MMP-7 protein in hypoxic macrophages (not only the intracellular levels) using zymography, western blotting and ELISA. Intracellular and secreted forms of pro-MMP-7 were shown to be upregulated by human MDM following 16 hours of exposure to hypoxia in vitro. The hypoxia up-regulated genes identified could be important for the survival and functioning of macrophages in hypoxic diseased tissues. |
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