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|b Hyperlipidemia and obesity are associated with many diseases which badly affective on health. Increased consumption of fruits is widely recommended to improve health and decrease overweight and the level of lipid in the blood. The aim of the present work is to study the effect of diet containing (apple, kiwi and combination of them) on the nutritional evaluation and biochemical parameters of rats. Suffering from high level of lipid and obesity. Seventy two albino male rats weighing 119±2 g used in this study. All rats fed on basal diet for two week for adaptation , after this period , rats divided in to two main groups , the first main group (8rats) fed on basal diet throughout the experimental periods (4 months) and considered as a negative control group , while the second main group fed on high fat diet for two months, then this group(n=64 rats) was divided in to eight subgroups (n = 8 rats of each ).The first four subgroups were continued fed on high fat diet with apple , kiwi and combination of them. However the other four subgroups fed on basal diet with apple, kiwi and combination of them. The eight subgroups were as followed, subgroup (1) positives control (1) fed on high fat diet .subgroups (2,3,4) fed on high fat diet containing (apple , kiwi and combination of them) respectively, subgroup(5) positive control (2) fed on basal diet. Subgroups (6, 7, 8) fed on basal diet containing (apple, kiwi and combination of them) respectively. The results revealed that found a significant increase in the body weight from positive control of high fat diet rat and obesity rat groups. Also increase a significant the level of lipid profile, liver enzymes and kidney function compared to negative control grope. While when feeding rats with high fat diet containing apple, kiwi and combination of them occur significant decrease in body weigh, liver enzymes , kidney function and level of lipid profile ( TC, TG, TL and LDL) and increase the level of HDL. And also when feeding obese rats with basal diet containing apple, kiwi and combination of them lead to significant decrease and improve body weigh, kidney function, liver enzymes and lipid profile (TC, TG, TL, LDL) and increase the level of HDL. In Histopathological study we find out change in cells liver, kidney, heart and brain in rats.
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