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Protective Effects of Honey on Carbon Tetrachloride Induced Hepatotoxicity in Rats

Source: مجلة العلوم الإنسانية والتطبيقية
Publisher: جامعة المرقب - كلية الآداب والعلوم قصر الأخيار
Main Author: Howas, Mahmoud Mohamed (Author)
Other Authors: Amer, Mohamed Ahmed (Co-Author)
Volume/Issue: ع10
Peer Refereed: Yes
Country: ليبيا
Date: 2020
Month: ديسمبر
Pages: 255 - 262
MD No.: 1104070
Content Type: بحوث ومقالات
Language: English
Database(s): HumanIndex
Subjects:
Author's keywords:
Liver | Hepatotoxic | Free Radical | Antioxidation
Online Access:
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041 |a eng 
044 |b ليبيا 
100 |a Howas, Mahmoud Mohamed  |e Author  |9 594360 
245 |a Protective Effects of Honey on Carbon Tetrachloride Induced Hepatotoxicity in Rats 
260 |b جامعة المرقب - كلية الآداب والعلوم قصر الأخيار  |c 2020  |g ديسمبر 
300 |a 255 - 262 
336 |a بحوث ومقالات  |b Article 
520 |b The present paper aimed to evaluate the hepatotoxic effects of carbon tetrachloride and the hepatoprotective effects of bees' honey on rats, the experiment was carried out on four groups of female Wister rats. Hepatic lesions were induced by intraperitoneal (i.p) injection of carbon tetrachloride (0.5 ml/Kg body weight (b.wt)) diluted in olive oil (0.5 ml/Kg with 1:1 ratio), twice a week a period of for four weeks. Biochemical parameters of hepatic damage such as serum aspartate aminotransferase (AST), alanine aminotransferase (ALT), lactate dehydrogenase (LDH) and catalase (CAT) activity were determined. Four weeks treatment using Carbon tetrachloride increased the serum AST, ALT and LDH levels significantly compared to control group (G1), while these enzymes were significantly reduced by the effect of honey (10%) plus CCl4 (0.5ml/Kg (b.wt) (i.p.)) for 4 weeks compared to CCl4 group (G3) (P<0.05), but there were significant decreases in catalase (CAT) values of CCl4 group (G3) compared to the control group (G1) (P<0.05). 
653 |a تسمم الكبد  |a المركبات الكيميائية  |a مضادات الأكسدة  |a العسل  |a الطب الوقائي 
692 |b Liver  |b Hepatotoxic  |b Free Radical  |b Antioxidation 
700 |9 594361  |a Amer, Mohamed Ahmed  |e Co-Author 
773 |4 العلوم الإنسانية ، متعددة التخصصات  |6 Humanities, Multidisciplinary  |c 017  |e Journal of Humanities and Applied Sciences  |l 010  |m ع10  |o 0630  |s مجلة العلوم الإنسانية والتطبيقية  |v 000 
856 |u 0630-000-010-017.pdf 
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995 |a HumanIndex 
999 |c 1104070  |d 1104070