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|b The origin in Salvia officinalis (Lamiaceae) is a wild plant belong to Mediterranean region. Since it is important and famous use become farm by wide spread in all the world and in flowering sunny conditions. Salvia plant traditionally used, proved to be very effective for treatment of various infections and diseases and newly in modem medicine because it contains estrogen, phenolic acids, flavonoids, resin, saponins, silica, tannins, volatile oils. Preliminary Phytochcmical screening was carried out on Petroleum ether extract of Salvia leaves which revealed the presence of Sterols, Volatile oils, Triterpenes, Alkaloid, 2- deoxy sugar, Flavone aglycone, Anthraquinones and Carbohydrates as the main natural components. The antimicrobial effect of Salvia leaves has been investigated in order to test their activity against four Bacterial strains, Escherichia coli (E.C), Pseudomonas aeruginosa, (PS) (Gram -vc) and Bacillus subtilis (B.S), Staphylococcus aureus (S.A) (Gram + ve) and two fungal strains Candida Albicans (CA), Aspergillus Niger (AS) in (50, 25, 12.5. 6.5) mg/ mL concentrations. Petroleum ether extract showed a strong and superior anti- bacterial activity against four species E.C, S.a, PS, B.S respectively. The results is revealed that E.C: (Gram -vc bacteria) has a high sensitivity. The chemical compositions of the petroleum extract were analyzed by gas chromatographic mass spectroscopic analysis (GC/MS), and 94 component were recorded. The major components were Eucahyptol (20.04%), Camphor (10.99%), Coumarinc, Beta.-Pinene, Thujone (0.62%), Borneol, 8-allyl-7-hydroxy-6-cth, Vitamine A aldehyde, Limonene-1,2- cpoxidc(fr.1), Ledol, Caryophyllene, 3- Cyclohexene-1-methanol,. alpha., Naphthalene, Bornyl acetate, Tridccane, Dodecane, D-Limonene, Undecane.
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