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The Prevalence of Anti-HBC Antibody among HBS Ag-Negative Libyan Blood Donors and its Association with HBV DNA in the Serum

المصدر: مجلة العلوم الإنسانية والتطبيقية
الناشر: الجامعة الأسمرية الإسلامية زليتن - كليتى الآداب والعلوم
المؤلف الرئيسي: Albakosh, Abdalla Muftah (Author)
مؤلفين آخرين: Alshwin, Farag Omar (Co-Author) , Arshah, Tarek Mohamed (Co-Author)
المجلد/العدد: ع30
محكمة: نعم
الدولة: ليبيا
التاريخ الميلادي: 2017
الشهر: يونيو
الصفحات: 76 - 82
رقم MD: 1260805
نوع المحتوى: بحوث ومقالات
اللغة: الإنجليزية
قواعد المعلومات: HumanIndex
مواضيع:
كلمات المؤلف المفتاحية:
HBV Infection | Anti-HBC | HBV-DNA | Blood Donors | Libya
رابط المحتوى:
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المستخلص: A hundred blood donors with hepatitis B surface antigen (HBs Ag) negative serology were enrolled in our study. These blood donors were investigated for the presence of antibodies to HBV core antigen (anti-HBc). Positive anti-HBc samples were further screened for anti-HBs antibodies, and for hepatitis B virus (HBV) DNA by real time Polymerase Chain Reaction technique. Results: The donors found to be Anti-HBc positive were 14 (represent 14% of all donors), among them 11 were positive for both Anti-HBcantibodies and anti-HBs antibodies, while three donors were positive for Anti-HBc antibodies alone. All Anti-HBc positive samples were investigated by Polymerase Chain Reaction technique and found to be negative for HBV-DNA (which it might be attributed to low sensitivity of the used Polymerase Chain Reaction technique). Despite that, it would be much safer to introduce anti-HBc screening for blood donors and discard all blood units which are positive for anti-HBc alone.

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