| المستخلص: |
Background: Colorectal cancer (CRC) is among the most common types of cancer in the world. CRC is common cancer in both males and females representing 4.5% and 3.6% of the total cancers. Hydrazines were manufactured from chemicals such as ammonia, dimethyl amine, hydrogen peroxide, and sodium hypochlorite .A small amount of hydrazine occurs naturally in some plants. 1, 2 Dimethyl hydrazine (DMH) has been used as a research chemical to produce colon cancer in lab animals. A therapeutic area in which NSAIDs use became important was in the treatment and prevention of cancer. Meloxicam was shown to prevent the initiation of chemical-induced tumors, and considered as anticancer agent by virtue of its anti-proliferative effect. Aims: The present study was designed to investigate the protective role of meloxicam which is a non-steroidal anti-inflammatory drug against colon cancer development. Methods: Sixty male albino mice were divided into five groups of 12 mice as follows: Group A: The animals were served as control; received S.C. injections of saline solution. Group B: The animals received S.C. injections of 20 mg 1, 2 DMH/ Kg b.w. Group C: The animals received 1, 2 DMH as in group B with ad libitum access to water and high fat diet. Group D: The animals were fed high fat diet and water ad libitum. Group E: The animals received S.C. injections of 1,2 DMH as in group B and oral 15mg/Kg /day meloxicam/0.1 ml saline via gastric tube 1 hour before DMH administration, fed high fat diet and water ad libitum. Results: there was elongation of the crypts with epithelial proliferation. Architectural disturbance, mitotic figures (MF), and inflammatory cells are observed in Colon sections of group C of animals received DMH – high fat diet. Colon sections of rats injected with DMH – Meloxicam -High fat diet in group E showed the majority of colonic glands with regular size and shape. Conclusion: The growth of aberrant crypt foci in colon was delayed or uncompleted after meloxicam use and this was shown to be a good evidence of its effectiveness in colon cancer protection.
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