| LEADER |
03022nam a22002297a 4500 |
| 001 |
2023849 |
| 041 |
|
|
|a eng
|
| 044 |
|
|
|b السودان
|
| 100 |
|
|
|a Ismeil, Abderrhman Ahmed Mohammed
|e Author
|9 676441
|
| 245 |
|
|
|a Preventive Effect of Meloxicam Against Colon Cancer Induced by 1, 2 Dimethyl Hydrazine in Rats
|
| 260 |
|
|
|b جامعة سنار
|c 2021
|g يناير
|
| 300 |
|
|
|a 11 - 22
|
| 336 |
|
|
|a بحوث ومقالات
|b Article
|
| 520 |
|
|
|b Background: Colorectal cancer (CRC) is among the most common types of cancer in the world. CRC is common cancer in both males and females representing 4.5% and 3.6% of the total cancers. Hydrazines were manufactured from chemicals such as ammonia, dimethyl amine, hydrogen peroxide, and sodium hypochlorite .A small amount of hydrazine occurs naturally in some plants. 1, 2 Dimethyl hydrazine (DMH) has been used as a research chemical to produce colon cancer in lab animals. A therapeutic area in which NSAIDs use became important was in the treatment and prevention of cancer. Meloxicam was shown to prevent the initiation of chemical-induced tumors, and considered as anticancer agent by virtue of its anti-proliferative effect. Aims: The present study was designed to investigate the protective role of meloxicam which is a non-steroidal anti-inflammatory drug against colon cancer development. Methods: Sixty male albino mice were divided into five groups of 12 mice as follows: Group A: The animals were served as control; received S.C. injections of saline solution. Group B: The animals received S.C. injections of 20 mg 1, 2 DMH/ Kg b.w. Group C: The animals received 1, 2 DMH as in group B with ad libitum access to water and high fat diet. Group D: The animals were fed high fat diet and water ad libitum. Group E: The animals received S.C. injections of 1,2 DMH as in group B and oral 15mg/Kg /day meloxicam/0.1 ml saline via gastric tube 1 hour before DMH administration, fed high fat diet and water ad libitum. Results: there was elongation of the crypts with epithelial proliferation. Architectural disturbance, mitotic figures (MF), and inflammatory cells are observed in Colon sections of group C of animals received DMH – high fat diet. Colon sections of rats injected with DMH – Meloxicam -High fat diet in group E showed the majority of colonic glands with regular size and shape. Conclusion: The growth of aberrant crypt foci in colon was delayed or uncompleted after meloxicam use and this was shown to be a good evidence of its effectiveness in colon cancer protection.
|
| 653 |
|
|
|a سرطان القولون والمستقيم
|a أمراض المعدة
|a العلاج الكيميائي
|
| 692 |
|
|
|b Colon Cancer
|b High Fat Diet
|b Meloxicam
|b 1, 2 Dimethyl Hydrazine
|
| 773 |
|
|
|c 005
|e Sinnar University journal for Applied Sciences
|l 002
|m مج1, ع2
|o 2394
|s مجلة جامعة سنار للعلوم التطبيقية
|v 001
|x 66860
|
| 856 |
|
|
|u 2394-001-002-005.pdf
|
| 930 |
|
|
|d y
|p y
|q n
|
| 995 |
|
|
|a EcoLink
|
| 995 |
|
|
|a science
|
| 999 |
|
|
|c 1270122
|d 1270122
|
