The Effect of Statin Drug Abused on Body Weight and Liver Enzymes Activity in Wister Rats
| المصدر: | مجلة الدراسات العليا |
|---|---|
| الناشر: | جامعة النيلين - كلية الدراسات العليا |
| المؤلف الرئيسي: | Salih, Nahid Mohamed (Author) |
| مؤلفين آخرين: | Maryoud, Amar Mohamed Ismail (Co-Author) |
| المجلد/العدد: | مج15, ع6 |
| محكمة: | نعم |
| الدولة: |
السودان |
| التاريخ الميلادي: |
2020
|
| الصفحات: | 79 - 83 |
| DOI: |
10.33914/1382-015-006-012 |
| ISSN: |
1858-6228 |
| رقم MD: | 1298462 |
| نوع المحتوى: | بحوث ومقالات |
| اللغة: | الإنجليزية |
| قواعد المعلومات: | EduSearch, EcoLink, IslamicInfo, HumanIndex |
| مواضيع: | |
| كلمات المؤلف المفتاحية: |
Statin | ALT | AST | Aminotransferases | Losing Weight | Sudan
|
| رابط المحتوى: |
| المستخلص: |
Background: Researchers proved the association between statins drugs and fatty liver. Recently in Sudan statin abused for losing weight. Herein we determined the effect of statin abused on liver enzymes and histological sections in Wistar rats. Materials and Methods: In experimental study, 18 male Wistar rats weighting (129.6±17.3g) were randomly divided into three groups, group one: received high dose statin (40mg/kg/day), group tow: received low dose (20 mg/kg/day) for twenty-one days and group three received placebo as control group. Body weight and weight gained were estimated at baseline, 7, 14 and 28 days. Serum Alaine Transaminase (ALT), Aspartate Transaminase (AST) and Alkaline Phosphatase (ALP) were measured using Mindray BC200 kinetic assay. Liver histological sections were examined. Results: The results showed that, statin significantly decreased body weight at day 7, while increased body weight at day 14 and 28. ALT and AST were significantly elevated after treatment. Histological section showed fatty liver following one-month statin abused. Conclusion: The data suggests that, abuse of statin drugs for losing weight had an adverse effect on liver functions. |
|---|---|
| ISSN: |
1858-6228 |
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