Impurity Analysis of Gentamicin Sulphate Injection Using Liquid Chromatography / Mass Spectrometry LC / MS
| المصدر: | مجلة بحوث جامعة تعز - سلسلة الآداب والعلوم الإنسانية والتطبيقية |
|---|---|
| الناشر: | جامعة تعز |
| المؤلف الرئيسي: | Saleh, Shaif Mohammed Kasem (Author) |
| مؤلفين آخرين: | Badulla, Wafa Farooq Suleman (Co-Author) , Al-Nawi, Safa Fadhel Mohammed (Co-Author) |
| المجلد/العدد: | ع34 |
| محكمة: | نعم |
| الدولة: |
اليمن |
| التاريخ الميلادي: |
2023
|
| الشهر: | يناير |
| الصفحات: | 87 - 98 |
| رقم MD: | 1365981 |
| نوع المحتوى: | بحوث ومقالات |
| اللغة: | الإنجليزية |
| قواعد المعلومات: | EduSearch, AraBase, HumanIndex |
| مواضيع: | |
| كلمات المؤلف المفتاحية: |
Impurity Analysis | Gentamicin | LC-MS | Liquid Chromatography
|
| رابط المحتوى: |
الناشر لهذه المادة لم يسمح بإتاحتها. |
| المستخلص: |
Gentamicin sulfate (GEN) is a broad-spectrum belonging to the group of aminoglycosides (AGs). The objective of the current study is the analysis of GEN injection impurity using reverse-Phase liquid chromatography and mass spectrometry. Five samples of GEN injection were selected from Abb governorate, and analyzed by LC/MS. The result showed that the lnj-I sample contained nineteen known impurities; m/zl63 deoxystreptamine, m/z 322 garamine, m/z 319 gentamine C1, VII-2, XK-62-5, Y-02077H- 6, gentamicin Cla in m/z 450, Y-02077H-y, XK-62-3, VII-1, gentamicins C2, C2a, and C2b in m/z 464 and m/z 478 gentamicin C1,garosamine m/z 177, m/z 448 sisomicin, at m/z 492 Y-02077H-6, XK-62-7and XK-62-8. In lnj-ll sample showed fourteen impurities same impurities as in the lnj-1 sample except for gentamineCl m/z 319 and impurities in m/z 492, and garosamine in m/z 177. While lnj-111 samples showed fifteen impurities same impurities as in the lnj-1 sample except for impurities in m/z 492 and m/z 177. In Inj-IV sample showed nineteen impurities same impurities as in the lnj-III sample except for m/z 448 sisomicin and impurity m/z482 J1-20A. In Inj-VI sample showed eighteen impurities same impurities as in the lnj-1 Rehaf sample except for garosamine in m/z 177. In addition of two unknown impurities in 490 and 110 except the lnj-ll sample did not show these impurities. |
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