Impurity Analysis of Gentamicin Sulphate Injection Using Liquid Chromatography / Mass Spectrometry LC / MS
| المصدر: | مجلة بحوث جامعة تعز - سلسلة الآداب والعلوم الإنسانية والتطبيقية |
|---|---|
| الناشر: | جامعة تعز |
| المؤلف الرئيسي: | Saleh, Shaif Mohammed Kasem (Author) |
| مؤلفين آخرين: | Badulla, Wafa Farooq Suleman (Co-Author) , Al-Nawi, Safa Fadhel Mohammed (Co-Author) |
| المجلد/العدد: | ع34 |
| محكمة: | نعم |
| الدولة: |
اليمن |
| التاريخ الميلادي: |
2023
|
| الشهر: | يناير |
| الصفحات: | 87 - 98 |
| رقم MD: | 1365981 |
| نوع المحتوى: | بحوث ومقالات |
| اللغة: | الإنجليزية |
| قواعد المعلومات: | EduSearch, AraBase, HumanIndex |
| مواضيع: | |
| كلمات المؤلف المفتاحية: |
Impurity Analysis | Gentamicin | LC-MS | Liquid Chromatography
|
| رابط المحتوى: |
الناشر لهذه المادة لم يسمح بإتاحتها. |
| LEADER | 02639nam a22002657a 4500 | ||
|---|---|---|---|
| 001 | 2117762 | ||
| 041 | |a eng | ||
| 044 | |b اليمن | ||
| 100 | |9 724425 |a Saleh, Shaif Mohammed Kasem |e Author | ||
| 245 | |a Impurity Analysis of Gentamicin Sulphate Injection Using Liquid Chromatography / Mass Spectrometry LC / MS | ||
| 260 | |b جامعة تعز |c 2023 |g يناير | ||
| 300 | |a 87 - 98 | ||
| 336 | |a بحوث ومقالات |b Article | ||
| 520 | |b Gentamicin sulfate (GEN) is a broad-spectrum belonging to the group of aminoglycosides (AGs). The objective of the current study is the analysis of GEN injection impurity using reverse-Phase liquid chromatography and mass spectrometry. Five samples of GEN injection were selected from Abb governorate, and analyzed by LC/MS. The result showed that the lnj-I sample contained nineteen known impurities; m/zl63 deoxystreptamine, m/z 322 garamine, m/z 319 gentamine C1, VII-2, XK-62-5, Y-02077H- 6, gentamicin Cla in m/z 450, Y-02077H-y, XK-62-3, VII-1, gentamicins C2, C2a, and C2b in m/z 464 and m/z 478 gentamicin C1,garosamine m/z 177, m/z 448 sisomicin, at m/z 492 Y-02077H-6, XK-62-7and XK-62-8. In lnj-ll sample showed fourteen impurities same impurities as in the lnj-1 sample except for gentamineCl m/z 319 and impurities in m/z 492, and garosamine in m/z 177. While lnj-111 samples showed fifteen impurities same impurities as in the lnj-1 sample except for impurities in m/z 492 and m/z 177. In Inj-IV sample showed nineteen impurities same impurities as in the lnj-III sample except for m/z 448 sisomicin and impurity m/z482 J1-20A. In Inj-VI sample showed eighteen impurities same impurities as in the lnj-1 Rehaf sample except for garosamine in m/z 177. In addition of two unknown impurities in 490 and 110 except the lnj-ll sample did not show these impurities. | ||
| 653 | |a كبريتات الجنتاميسين |a الأمينوغليكوزيدات |a المواد الكيميائية | ||
| 692 | |b Impurity Analysis |b Gentamicin |b LC-MS |b Liquid Chromatography | ||
| 700 | |9 724419 |a Badulla, Wafa Farooq Suleman |e Co-Author | ||
| 700 | |9 724421 |a Al-Nawi, Safa Fadhel Mohammed |e Co-Author | ||
| 773 | |4 الادب |4 العلوم الاجتماعية ، متعددة التخصصات |6 Literature |6 Social Sciences, Interdisciplinary |c 008 |e University of Taiz Research Journal - Arts and Humanities |l 034 |m ع34 |o 0931 |s مجلة بحوث جامعة تعز - سلسلة الآداب والعلوم الإنسانية والتطبيقية |v 000 | ||
| 856 | |u 0931-000-034-008.pdf | ||
| 930 | |d n |p y |q n | ||
| 995 | |a EduSearch | ||
| 995 | |a AraBase | ||
| 995 | |a HumanIndex | ||
| 999 | |c 1365981 |d 1365981 | ||
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