Combination of LT-12 and TM-03 Drugs is a Highly Effective Treatment of Stroke and Cerebral Palsy: From Experimental to Clinical Studies
| المصدر: | المجلة العربية للنشر العلمي |
|---|---|
| الناشر: | مركز البحث وتطوير الموارد البشرية - رماح |
| المؤلف الرئيسي: | Huria, Tahani R (Author) |
| المجلد/العدد: | ع14 |
| محكمة: | نعم |
| الدولة: |
الأردن |
| التاريخ الميلادي: |
2019
|
| الشهر: | ديسمبر |
| الصفحات: | 532 - 539 |
| ISSN: |
2663-5798 |
| رقم MD: | 1435609 |
| نوع المحتوى: | بحوث ومقالات |
| اللغة: | الإنجليزية |
| قواعد المعلومات: | EduSearch, HumanIndex |
| مواضيع: | |
| كلمات المؤلف المفتاحية: |
Brain "Rons" | Ischaemia | Adult and Neonatal Rats "Albino Species" | LT-12 & TM-03
|
| رابط المحتوى: |
| المستخلص: |
Stroke and cerebral palsy are common ischaemic brain problems in adult and neonate over the world. Both constitute one of the most devastating neurological disorders and are the third leading cause of death in developing countries. The non-availability of data about stroke and cerebral palsy has limited research output and both are underestimated by government and health ministry in developing countries. In this study, the albino rat`s brain was subjected to ischaemic injury (oxygen & glucose deprivation (OGD) using optic nerves. The brain of both adult and neonatal rats was subjected to ischaemia for a period of time (2 hrs.). The function of the brain was monitored before, during and after ischaemic insult where the drugs are administered by using electronmicroscopy (recording the compound action potential (CAP)). Optic nerves lost their function significantly following OGD in-compare to control in both adult and neonate. Administration of 1μM LT-12 and 100 μM TM-03 each of them alone has very high protection against ischaemic injury in both adult and neonatal rats. Combination of 1μM LT-12 and 100 μM TM-03 lead to highly significant and nearly complete protection against brain ischaemia in both adult and neonate. The last result was confirmed by using electron microscopy for structural changes before and after administration of 1μM LT-12 and 100 μM TM-03 together in albino rats. The brain structures of albino rats were reversed to normal after administration of both drugs together. The result indicating that the combin |
|---|---|
| ISSN: |
2663-5798 |
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