The Antibacterial Activity of 5-Fluoro-Isatin Thiosemicarbazone Derivatives on some Pathogenic Bacteria
| المصدر: | مجلة التربوي |
|---|---|
| الناشر: | جامعة المرقب - كلية التربية بالخمس |
| المؤلف الرئيسي: | Soof, Sana Ali (Author) |
| مؤلفين آخرين: | Sauf, Mona A. (Co-Author) , Shakurfow, Fathi Abdallah (Co-Author) , Kahal, Fatma (Co-Author) |
| المجلد/العدد: | ع24 |
| محكمة: | نعم |
| الدولة: |
ليبيا |
| التاريخ الميلادي: |
2024
|
| الشهر: | يناير |
| الصفحات: | 892 - 898 |
| ISSN: |
2011-421X |
| رقم MD: | 1455275 |
| نوع المحتوى: | بحوث ومقالات |
| اللغة: | الإنجليزية |
| قواعد المعلومات: | EduSearch |
| مواضيع: | |
| كلمات المؤلف المفتاحية: |
5-Fluoro-Isatin Thiosemicarbazone | Antibacterial Activity | Gram Negative Bacteria
|
| رابط المحتوى: |
| المستخلص: |
Isatin based materials can exhibit a wide range of biological activities including antimicrobial, antiviral, antifungal, anthelmintic, antitumor, anti-HIV, anti-inflammatory, antidepressant, antioxidant, anticonvulsant, antitubercular, analgesic, and central nervous system depressant activities. In this study, six compounds containing 5-Fluoro-isatin thiosemicarbazone with fluorophenyl and nitrophenyl or fluorophenyl and nitrophenyl in different positions and zinc complexes were evaluated based on their biological activities. 5-Fluoro isatin -3-(N-2- Fluorophenyl) Thiosemicarbazone and 5-Fluoro isatin-3-(N-4-Nitro phenyl) Thiosemicarbazone were the strongest compounds affecting gram positive bacteria compared to the other compounds. Also, this compound indicated better antimicrobial activity than positive control antibiotics. Besides, 5-Fluoro isatin-3- (N-4- Fluorophenyl) Thiosemicarbazone showed large inhibition zone equal to 13 mm against to some gram negative bacteria such as Klebsiella pneumonia and Serratia marrescens. |
|---|---|
| ISSN: |
2011-421X |
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