Potential Anticancer Effect of Cape Gooseberry Fruit Juice on Rats with Induced-Colon Cancer
| المصدر: | المجلة العلمية للتربية النوعية والعلوم التطبيقية |
|---|---|
| الناشر: | جامعة الفيوم - كلية التربية النوعية |
| المؤلف الرئيسي: | Elgazar, Aml F. (Author) |
| مؤلفين آخرين: | Shalaby, Mostafa A. (Co-Author) , Aboraya, Alaa Osama (Co-Author) |
| المجلد/العدد: | مج6, ع15 |
| محكمة: | نعم |
| الدولة: |
مصر |
| التاريخ الميلادي: |
2023
|
| الشهر: | يناير |
| الصفحات: | 240 - 262 |
| ISSN: |
2682-3101 |
| رقم MD: | 1501247 |
| نوع المحتوى: | بحوث ومقالات |
| اللغة: | الإنجليزية |
| قواعد المعلومات: | EduSearch |
| مواضيع: | |
| كلمات المؤلف المفتاحية: |
Cape Gooseberry Fruit | Dimethy lhydrazine | Colon Cancer | Anti-Inflammatory | Antioxidant | Hepatorenal Functions | Histopathology
|
| رابط المحتوى: |
الناشر لهذه المادة لم يسمح بإتاحتها. |
| LEADER | 03098nam a22002417a 4500 | ||
|---|---|---|---|
| 001 | 2245013 | ||
| 041 | |a eng | ||
| 044 | |b مصر | ||
| 100 | |a Elgazar, Aml F. |e Author |9 796756 | ||
| 245 | |a Potential Anticancer Effect of Cape Gooseberry Fruit Juice on Rats with Induced-Colon Cancer | ||
| 260 | |b جامعة الفيوم - كلية التربية النوعية |c 2023 |g يناير | ||
| 300 | |a 240 - 262 | ||
| 336 | |a بحوث ومقالات |b Article | ||
| 520 | |b Colon cancer is one of the most common cancers influencing the gastrointestinal tract and the second leading cause of cancer deaths. Nowadays, non-traditional fruits such as Cape gooseberry play an important role in human nutrition and as an excellent source of bioactive phytochemicals. This study was directed to explore the potential anticancer effect of Cape gooseberry fruit on rats with colon cancer. Fifty male albino rats 6-8 weeks old and weighing 195 ±10 g were distributed into five groups of 10 rats each. Rats in group 1 were kept normal control and subcutaneously injected with 0.1 mL of the saline solution once weekly during the experimental period (12 weeks). Rats in groups 2, 3, 4, and 5 were subcutaneously injected once weekly with 35 mg/kg b. wt of 1, 2-Dimethylhydrazine (DMH) during the experimental period. Rats in group 2 were kept as Positive control. Rats in groups 3, 4, and 5 were given orally Cape gooseberry fruit juice (CGFJ) along with injected DMH. In comparison to normal control rats, administration of DMH caused significant decreases in body weight gain, and serum total protein and albumin levels as well as activities of GPx, CAT and GSH enzymes. Administration of CGFJ caused significant increases in serum levels of tumor biomarkers AFP, TNF-α, NF-κ β, UN, UA, Cr and MDA, as well as the total number of leukocytes, lymphocytes, monocytes and liver enzymes activities including AST, ALT and ALP. Oral administration of the different levels of CGFJ to rats injected with DMH caused significant amelioration in all of the above-mentioned parameters. The best results were obtained in the treated groups with high levels of CGFJ. The biochemical results were nearly consistent with the histopathological findings, which confirmed the positive effect of the CGFJ against DMH-induced colon cancer. In conclusion, CGFJ exhibited antioxidant and antiinflammatory activities and protective effects against colon cancer and dysfunction of the liver and kidney in rats injected by DMH. | ||
| 653 | |a الأمراض الخبيثة |a سرطان القولون |a فاكهة عنب الثعلب |a مصر | ||
| 692 | |b Cape Gooseberry Fruit |b Dimethy lhydrazine |b Colon Cancer |b Anti-Inflammatory |b Antioxidant |b Hepatorenal Functions |b Histopathology | ||
| 700 | |9 796757 |a Shalaby, Mostafa A. |e Co-Author | ||
| 700 | |a Aboraya, Alaa Osama |e Co-Author |9 555823 | ||
| 773 | |c 008 |l 015 |m مج6, ع15 |o 2576 |s المجلة العلمية للتربية النوعية والعلوم التطبيقية |v 006 |x 2682-3101 | ||
| 856 | |u 2576-006-015-008.pdf | ||
| 930 | |d n |p y |q n | ||
| 995 | |a EduSearch | ||
| 999 | |c 1501247 |d 1501247 | ||
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