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الرئيسية > Exploring the Clinical and Lab...>الوصف

Exploring the Clinical and Laboratory Aspects of Novel Coronavirus Infection "COVID-19": A Systematic Review

المصدر: المجلة العربية للنشر العلمي
الناشر: مركز البحث وتطوير الموارد البشرية - رماح
المؤلف الرئيسي: Sharefe, Mohammad Ali Yahya (Author)
مؤلفين آخرين: Alshahrani, Abdullah Hussain Ali (Co-Author) , Asiri, Zayed Ahmed Zayed (Co-Author) , Albaqami, Sultan Hamoud Mohammed (Co-Author) , Al Shalan, Yasir Saad Saeed (Co-Author)
المجلد/العدد: ع71
محكمة: نعم
الدولة: الأردن
التاريخ الميلادي: 2024
الشهر: أيلول
الصفحات: 934 - 940
ISSN: 2663-5798
رقم MD: 1547410
نوع المحتوى: بحوث ومقالات
اللغة: الإنجليزية
قواعد المعلومات: EduSearch, HumanIndex
مواضيع:
العدوى الفيروسية | أمراض المناعة | جائحة كورونا "كوفيد-19"
كلمات المؤلف المفتاحية:
COVID-19 | SARS-Cov-2 | Immunological Assays | Reverse Transcriptase-Polymerase Chain Reaction | Biomarkers | Clinical Pathology
رابط المحتوى:
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المستخلص: COVID-19 is a highly transmissible illness caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The World Health Organization (WHO) declared it a pandemic in 2020, following its rapid global spread. While the virus can lead to severe illness, particularly among vulnerable groups such as the elderly, individuals with compromised immune systems, diabetics, those with heart conditions, and patients with hypertension, many infected individuals remain asymptomatic or exhibit mild to moderate respiratory symptoms. The most critical manifestation of COVID-19 is often marked by a cytokine storm (A cytokine storm: is an intense immune response marked by the excessive release of pro-inflammatory cytokines into the bloodstream. This can cause widespread inflammation and tissue damage across multiple organs. Commonly linked to severe infections, autoimmune diseases, and conditions like COVID-19, symptoms may include fever, fatigue, and respiratory distress. If untreated, it can lead to serious complications or death. Management typically focuses on reducing inflammation and moderating the immune response.) The definitive laboratory diagnosis relies on the identification of viral ribonucleic acid (RNA) through real -time polymerase chain reaction (RT-PCR) testing of samples obtained from nasal and oropharyngeal swabs. This testing method is most effective when conducted in the initial days following symptom onset. Serological tests play a crucial role in assessing the immune response, as both IgM and IgG antibodies can be detected approximately seven days after the onset of symptoms and may persist for over 200 days. However, the presence of antibodies does not necessarily indicate that an individual is no longer infectious, as this depends on their viral load and clinical status. Utilizing specific laboratory markers judiciously is essential, considering the disease's progression. Proper interpretation of these markers can enhance patient management, facilitate the identification of asymptomatic carriers, and assist in monitoring those with mild symptoms.
ISSN: 2663-5798

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