| المستخلص: |
This research designed to study the Protective of the aqueous ecxtract of Cymbopogon citratus on male reproductive system of rats that exposed to oxidative stress induced by hydrogen peroxide 0.5% with drinking water alonge the period of experiment (30 days). The study contribute the comparism between the effect of Cymbopogon citratus with vit.E effect as will known antioxidant . The results show Compared with the control group the oxidative stress induced by H2O2 lead to significant decrease in body weight, testis and epididymis weights with asignificant decrease of total sperm count , percentages of motile and normal sperms, levels of Glutathion and testosterone hormone in H2O2 group . The results also show a significant increase in the percentages of dead and abnormal sperms , MDA level in comparism with to control group . In other hand the rats that exposed to oxidative stress treated by Combopogon citratues extraction ( 100mg /Kg body weight) or vit. E (500mg /Kg body weight) show significant increase in body weight , testis and epididmis weights , total sperm count, percentages of motile and normal . dead abnormal sperms, Glutathion and testostrone hormone levels this treatment decreas in total sperm count percentages of motile and normal sperms and MDA level comparism to a group treated by hydrogen peroxide ( P<0.05 ). The rats that treated by Cymbopogen citratus (100 mg/Kg body weight) alone show significant in total sperm count , percentages of motile sperms , at the some time show non significant changes in body weight ,testeis and epididymis weights , percentages of normal sperms and the levels of Glutathion and testosterone ,while the effect of extract show significant decrease the percentages of dead sperm , MDA level . Compared to control group . The registerated result regarding the histopathological changes in testicular tissue of male rats treated by hydrogen peroxide such as damage of seminephrous tubules necrosis, accumulation of dead cells in the tubules cavity ,slugthred Sertoli cell from basal membrane and vaculation appear in some section . Also healing appear in testeis of rats that had received hydrogen peroxide when treated by Cymbopogen citratus and vit .E. Conclusion this study include the important role of Cymbopogen citratus aqueous extract as antioxidant against some species of the free radicals in the body with comparism to vit.E ,that known as an important antioxidant and then normalize the most important in Biochmical and physiological chang in male reproductive system . When exposed to oxidation stress by hydrogen peroxide H2O2 .
|
