Haematopoietic Stem Cell Transplantation in a Mouse Model of Multiple Sclerosis
| المؤلف الرئيسي: | Al Bugami, Raef R. (Author) |
|---|---|
| مؤلفين آخرين: | Petratos, Steven (Advisor) |
| التاريخ الميلادي: |
2011
|
| موقع: | ملبورن |
| الصفحات: | 1 - 31 |
| رقم MD: | 620180 |
| نوع المحتوى: | رسائل جامعية |
| اللغة: | الإنجليزية |
| الدرجة العلمية: | رسالة ماجستير |
| الجامعة: | RMIT University |
| الكلية: | School of Medical Science |
| الدولة: | أستراليا |
| قواعد المعلومات: | +Dissertations |
| مواضيع: | |
| رابط المحتوى: |
الناشر لهذه المادة لم يسمح بإتاحتها. |
| المستخلص: |
Haematopoietic stem cells (HSCs) are a group of cells that can renew themselves and differentiate to give rise to all blood cells including immune cells. HSCs have been used to treat many malignant and non-malignant disorders including autoimmune diseases such as multiple sclerosis (MS). MS is an inflammatory disease where immune mediated damage occurs at myelin sheath in the brain and spinal cord manifesting clinically as complete disability of the patient. Moreover, the presence of myelin regrowth inhibitory factor (Nogo-A) can impair the process of remyelination and axonal regeneration. We have used enhanced green fluorescent protein (eGFP)-expressing HSCs and precursors in a preliminary proof of principle experiment for engraftment in the spinal cord at the lesion site in an experimental autoimmune encephalomyelitis (EAE) - an animal model of MS. We tested the capability of transplanted eGFP-expressing HSCs to migrate to the lesion sites by crossing blood-brain barrier (BBB) in EAE mouse model of MS, by localizing the eGFP signal in inflammatory spinal cord. The process of immunoselection of HSCs revealed that CD117 marker could be as important as CD34 in identifying and isolating HSCs. Therefore, it would seem that CD117 enriched HSCs is an excellent marker to be used for transplantation. |
|---|
عناصر مشابهة
-
Defining the Immunophenotype of Transplanted Haematopoietic Stem Cells in a Mouse Model of Multiple Sclerosis
بواسطة: Bakhuraysah, Maha Mahfouz منشور: (2011) -
Parents’ Experiences of their Children’s Haematopoietic Stem Cell Transplantation: An Integrative Literature Review
بواسطة: Al Mansour, Ahmed منشور: (2012) -
Effective treatment and prevention of Graft versus host disease (GvHD) in allogeneic -haematopoietic stem cell transplantation (Allo-HSCT) : Resolutions to reduce morbidity and mortality
بواسطة: Arkook, Ahaleed Yousef منشور: (2011) -
Neurogenic Differentiation Potential and Immunomodulatory Activity of Mesenchymal Stem Cells "Mscs" from Multiple Sclerosis Patients
بواسطة: الجمالي، فاطمة عباس فاضل منشور: (2016) -
Invariant Natural Killer T Cells in Multiple Sclerosis
بواسطة: Kamel, Fatemah Omar منشور: (2010)
