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|a eng
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|9 10442
|a Al Bugami, Raef R.
|e Author
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| 245 |
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|a Haematopoietic Stem Cell Transplantation in a Mouse Model of Multiple Sclerosis
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|a ملبورن
|c 2011
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|a 1 - 31
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| 336 |
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|a رسائل جامعية
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| 502 |
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|b رسالة ماجستير
|c RMIT University
|f School of Medical Science
|g أستراليا
|o 0007
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|a Haematopoietic stem cells (HSCs) are a group of cells that can renew themselves and differentiate to give rise to all blood cells including immune cells. HSCs have been used to treat many malignant and non-malignant disorders including autoimmune diseases such as multiple sclerosis (MS). MS is an inflammatory disease where immune mediated damage occurs at myelin sheath in the brain and spinal cord manifesting clinically as complete disability of the patient. Moreover, the presence of myelin regrowth inhibitory factor (Nogo-A) can impair the process of remyelination and axonal regeneration. We have used enhanced green fluorescent protein (eGFP)-expressing HSCs and precursors in a preliminary proof of principle experiment for engraftment in the spinal cord at the lesion site in an experimental autoimmune encephalomyelitis (EAE) - an animal model of MS. We tested the capability of transplanted eGFP-expressing HSCs to migrate to the lesion sites by crossing blood-brain barrier (BBB) in EAE mouse model of MS, by localizing the eGFP signal in inflammatory spinal cord. The process of immunoselection of HSCs revealed that CD117 marker could be as important as CD34 in identifying and isolating HSCs. Therefore, it would seem that CD117 enriched HSCs is an excellent marker to be used for transplantation.
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|a الخلايا الجذعية
|a التصلب المتعدد
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| 700 |
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|9 44002
|a Petratos, Steven
|e Advisor
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| 856 |
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|u 9843-001-004-0007-T.pdf
|y صفحة العنوان
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| 856 |
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|u 9843-001-004-0007-A.pdf
|y المستخلص
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|u 9843-001-004-0007-C.pdf
|y قائمة المحتويات
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| 856 |
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|u 9843-001-004-0007-F.pdf
|y 24 صفحة الأولى
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| 856 |
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|u 9843-001-004-0007-1.pdf
|y 1 الفصل
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| 856 |
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|u 9843-001-004-0007-2.pdf
|y 2 الفصل
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| 856 |
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|u 9843-001-004-0007-3.pdf
|y 3 الفصل
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| 856 |
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|u 9843-001-004-0007-4.pdf
|y 4 الفصل
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| 856 |
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|u 9843-001-004-0007-R.pdf
|y المصادر والمراجع
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| 930 |
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|d n
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| 995 |
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|a +Dissertations
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|c 620180
|d 620180
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