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Transfusion Management for Patients with Sickle Cell Disease

المؤلف الرئيسي: Al Battal, Fahad Mohammad (Author)
التاريخ الميلادي: 2011
موقع: ملبورن
الصفحات: 1 - 25
رقم MD: 752494
نوع المحتوى: رسائل جامعية
اللغة: الإنجليزية
الدرجة العلمية: رسالة ماجستير
الجامعة: RMIT University
الكلية: School of Medical Science
الدولة: أستراليا
قواعد المعلومات: +Dissertations
مواضيع:
رابط المحتوى:

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المستخلص: Sickle cell disease (SCD) is considered a multisystem disease caused by the inheritance of the mutated hemoglobin S (HbS). the diseases involves two common features, sickle shaped erythrocytes and the presence of several complications related to the disease, such as, stroke, anemia, vaso-occlusive and multi organ failure. The disease is treated mainly through three techniques: hydroxyurea, bone marrow transplantation and blood transfusion. Blood transfusion is considered the most common therapy among the three. This review focuses on the techniques used to reduce the complications of blood transfusion in patients who have SCD. The review’s content has been gathered electronically through exploring RMIT library database which includes Science Direct website, First Web of Knowledge website and Pub Med website.Basedupon six studies covered the topic the reduction of blood transfusion complication in sickle cell disease patients the result showed that automated erythrocytapheresis (ECP)Procedure is the most promising transfusion method, it reduces HbS levels to less than 30% of the total Hb in the body,and it prevents iron overload. In addition, it is noted that the procedure minimizes the alloimmunization and transmission infectious diseases. ECP is considered a beneficial therapy since it controls SCD complications and improves the patient’s clinical outcome.