Changes in Oxidative Stress-Related Biomarkers May Have a Role in The Pathophysiological Mechanisms Involved in Autism
| المصدر: | المجلة العربية للعلوم ونشر الأبحاث |
|---|---|
| الناشر: | المركز القومي للبحوث بغزة |
| المؤلف الرئيسي: | Abd El-hamid, Shadia (Author) |
| مؤلفين آخرين: | Sherif, Naglaa Mostafa (Co-Author) , Ezz-eldine, Nermine (Co-Author) |
| المجلد/العدد: | مج1, ع1 |
| محكمة: | نعم |
| الدولة: |
فلسطين |
| التاريخ الميلادي: |
2015
|
| الصفحات: | 41 - 46 |
| DOI: |
10.26389/AJSRP.S05216 |
| ISSN: |
2518-5780 |
| رقم MD: | 776782 |
| نوع المحتوى: | بحوث ومقالات |
| اللغة: | الإنجليزية |
| قواعد المعلومات: | HumanIndex |
| مواضيع: | |
| كلمات المؤلف المفتاحية: |
Autism Spectrum disorder | Nitric oxide | reactive oxygen species | Oxidative stress
|
| رابط المحتوى: |
عدد مرات التحميل
61
| المستخلص: |
There is evidence that oxygen free radicals play a vital part in the pathophysiology of numerous neuropsychiatric disorders. Although it has not been investigated yet, several recent studies proposed that nitric oxide (NO) and other parameters related to oxidative stress may have a pathophysiological role in autism. This study aims to evaluate the plasma levels of antioxidant enzyme, superoxide dismutase (SOD) and plasma level of Nitric oxide (NO), a marker of oxidative stress, in Egyptian autistic children. Autism is a neurodevelopmental disorder of childhood with poorly understood etiology and pathology. The present study included 40 children with autism diagnosed by DSM-V-TR criteria and Childhood Autism Rating Scale. Controls included 40 age-matched healthy children. Cases were referred to Outpatient Clinic of Children with Special Needs Department, National Research Center, Cairo, Egypt. We compared levels of SOD, and NO in children with autism and controls. Level of NO was significantly higher in autistic children compared with their controls, while SOD was significantly lower among patients than controls. These findings indicate a possible role of increased oxidative stress and altered enzymatic antioxidants, both of which may be relevant to the pathophysiology of autism. |
|---|---|
| ISSN: |
2518-5780 |
عناصر مشابهة
-
Oxidative Stress Biomarkers in Rheumatoid Arthritis Patients
بواسطة: الحروب، هاشم أيمن أنور منشور: (2023) -
The Role of ERF6 in Regulating Oxidative Stress and the Importance of the ELLEL Conserved Motif for MED25 Interaction
بواسطة: Fallath, Thorya منشور: (2012) -
Biomarkers of Oxidative Stress in Patients Undergoing Coronary Artery By-Pass Graft Surgery (CABG)
بواسطة: Al Muzaini, Tariq Salman منشور: (2008) -
Oxidative Stress and Zine Status in Children with b-Thalassemia Major and its Relation to Growth Retardation
بواسطة: Ali, Magdy Karam El-Din منشور: (2014) -
A Biochemical Comparative Study of Oxidative Stress and Lipid Profile in Elderly Patients With Atrial Fibrillation in Thi-Qar Governorate/Iraq
بواسطة: ساير، ساره عاشور منشور: (2017)
