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GSTM1 polymorphisms and Severity of Sickle Cell Anaemia

المؤلف الرئيسي: Jamel, Saadia Osman Abd Alraheem (Author)
مؤلفين آخرين: Khalil, Hiba Badreldin (Advisor)
التاريخ الميلادي: 2017
موقع: الخرطوم
الصفحات: 1 - 76
رقم MD: 831603
نوع المحتوى: رسائل جامعية
اللغة: الإنجليزية
الدرجة العلمية: رسالة ماجستير
الجامعة: جامعة النيلين
الكلية: كلية الدراسات العليا
الدولة: السودان
قواعد المعلومات: Dissertations
مواضيع:
رابط المحتوى:
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LEADER 03146nam a22003257a 4500
001 1472821
041 |a eng 
100 |9 446840  |a Jamel, Saadia Osman Abd Alraheem  |e Author 
245 |a GSTM1 polymorphisms and Severity of Sickle Cell Anaemia 
260 |a الخرطوم  |c 2017 
300 |a 1 - 76 
336 |a رسائل جامعية 
502 |b رسالة ماجستير  |c جامعة النيلين  |f كلية الدراسات العليا  |g السودان  |o 0327 
520 |a Background: Sickle cell anemia (SCA) is a genetic disorder caused by homozygosity for a single β-globin gene mutation (β6GAG→GTG), in which glutamic acid has been substituted for valine at the sixth codon of β-globin chain. Despite this fact, the clinical course of patients suffering from SCA is extremely variable, the severity of manifestations ranging from asymptomatic to a very severe course. The phenotypic variability maybe explained by some genetic factors, those related to globin genes have been well recognized. Severity of sickle cell anaemia (SCA) results from sickling of Hb S due to oxidation, which is augmented by accumulation of oxygen-free radicals. The glutathione system plays an important role in the removal of endogenous products of peroxidation of lipids, thus protecting cells and tissue against damage from oxidative stress. Impairment of the glutathione system due to genetic polymorphisms of glutathione S-transferase (GST) genes is expected to increase the severity of SCA manifestations. Objectives: This study aimed to determine the frequency of GSTM1 gene polymorphisms and its association with the severity of SCA among Sudanese patients. Materials and Methods: GSTM1gene polymorphisms were determined by multiplex polymerase chain reaction (PCR). Results: The frequency of GSTM1 null was higher in SCA patients compare with the positive gene patients. No significant correlation was found between the GSTM1 null age and gender (P.value >0.05). On the other hand a significance difference in hemoglobin concentration, packed cell volume and red cell count results between GSTM1 null patient's and GSTM1positive patients (P.value< 0.05). Conclusion: The GSTM1null were significantly associated with increased severity of sickle cell anemia among Sudanese patients. 
653 |a الدم  |a فقر الدم  |a أمراض الدم  |a المرضى السودانيين 
700 |a Khalil, Hiba Badreldin  |e Advisor  |9 444658 
856 |u 9818-006-001-0327-T.pdf  |y صفحة العنوان 
856 |u 9818-006-001-0327-A.pdf  |y المستخلص 
856 |u 9818-006-001-0327-C.pdf  |y قائمة المحتويات 
856 |u 9818-006-001-0327-F.pdf  |y 24 صفحة الأولى 
856 |u 9818-006-001-0327-1.pdf  |y 1 الفصل 
856 |u 9818-006-001-0327-2.pdf  |y 2 الفصل 
856 |u 9818-006-001-0327-3.pdf  |y 3 الفصل 
856 |u 9818-006-001-0327-4.pdf  |y 4 الفصل 
856 |u 9818-006-001-0327-5.pdf  |y 5 الفصل 
856 |u 9818-006-001-0327-R.pdf  |y المصادر والمراجع 
856 |u 9818-006-001-0327-S.pdf  |y الملاحق 
930 |d y 
995 |a Dissertations 
999 |c 831603  |d 831603