Microwave Assisted Synthesis Characterization and Biological Studies of N-isonicotinamido 2,3 Dihydroxybenzaldimine and its Metal Complexes
| المصدر: | مجلة رواق المعرفة |
|---|---|
| الناشر: | جامعة طرابلس - كلية التربية بجنزور |
| المؤلف الرئيسي: | Alarabi, Hussain I. (Author) |
| مؤلفين آخرين: | Suayed, Wahiba A. (Co-Author) |
| المجلد/العدد: | ع1,2 |
| محكمة: | نعم |
| الدولة: |
ليبيا |
| التاريخ الميلادي: |
2014
|
| الصفحات: | 80 - 98 |
| رقم MD: | 838132 |
| نوع المحتوى: | بحوث ومقالات |
| قواعد المعلومات: | +HumanIndex |
| مواضيع: | |
| رابط المحتوى: |
عدد مرات التحميل
3
| المستخلص: |
Complexes of Co(II), Ni(II), Cu(II) and Zn(II) with the Schiff base N-isonicotinamido- 2,3-dihydroxybenzaldimine (ligand), which was formed by the condensation of isonicotinic acid hydrazide (isoniazid) with 2, 3-dihydroxybenzaldehyde, have been synthesized by microwave methods. The chemical structure of the Schiff base and its complexes were characterized by various spectroscopic studies, which included IR, UV- VIS, ‘H NMR, ‘X NMR, El mass spectrometry, elemental analysis, and thermogravimetric studies. The complexes have the general formulae [M(L)2].nH20, where M= Zn(II), Co(II) and Cu(II) and [M(L)H20](0Ac).nH20, where M= Ni(II) {L= N-isonicotinamido-2,3-dihydroxybenzaldimine}. The Schiff base behaves as a monoanionic tridentate O, N and O-donor ligand. It coordinates to each metal atom through the carbonyl oxygen, azomethine nitrogen and phenolic oxygen. Octahedral geometries were assigned to the Zn (II), Co (II) and Cu (II) complexes and a tetrahedral geometry was assigned to the Ni (II) complex. The biological activities of the ligand and its complexes were tested on Gram positive bacteria (Escherichia coli) and Gram negative bacteria (Staphylococcus aurous) and two fungi (Aspergillus flavus and Candida albicans). The biological activity data show that some metal complexes are more potent than of the free ligand. |
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