Synthesis and Biological Activity of Some New 2-(2,4 dimethoxyphenylpyrrolo [2,3-d] Pyrimidine Compounds
| المصدر: | مجلة جامعة الزيتونة |
|---|---|
| الناشر: | جامعة الزيتونة |
| المؤلف الرئيسي: | Musa, Suliman M. (Author) |
| المجلد/العدد: | ع12 |
| محكمة: | نعم |
| الدولة: |
ليبيا |
| التاريخ الميلادي: |
2014
|
| الصفحات: | 66 - 79 |
| DOI: |
10.35778/1742-000-012-023 |
| ISSN: |
2523-1006 |
| رقم MD: | 840427 |
| نوع المحتوى: | بحوث ومقالات |
| قواعد المعلومات: | EcoLink, EduSearch, IslamicInfo, HumanIndex |
| مواضيع: | |
| رابط المحتوى: |
عدد مرات التحميل
7
| المستخلص: |
The present work is aimed to synthesize some new heterocyclic compounds containing pyrrolo[2,3-d]pyrimidines, Our approach to the synthesis of the target compounds started through the hydrolysis of 6-ethylthio-4-methyl-2-(2'',4'- dimethoxyphenyl)pyi imidine-5-carbonitrile (2) by refluxing in ethanol containing sodium hydroxide to give the corresponding sodium salt derivative (3) which in turn wais acidified to give 5-cyano-4-niethyl-2-(2 A- dimethoxyphenyl)pyrimidin-6(H)one (4). Chlorination of the hydroxy derivative (4) afforded 6-Chloro-4-methyl-2-(2\4'- dimethoxyphenyl)pyrimidin-5-carbonitrile (5), which reacted with ethyl glycinate hydrochloride.to give Ethyl (5-cyano-4-methyl-2-(2\4'- dimethoxyphenyl)yrimidin-6-yloxy)acetate (6),which underwent cyclization to give the ethyl 5-amino-4-methyl-2-(2,4'-dimethoxyphenyl)-7H- pyrrolo[2,3-d]pyrimidine-6-carboxylate (10). Also the reaction of compound (5) with piperidine, and morpholine, gave the piperidino- and morphilino- derivatives (7) and (8) respectively. The compound (10) was used as key intermediates in the synthesis of other new pyrrolo[2,3-d]pyrimidine derivatives (11-13), pyrimido[4\5\4,5]pyrrolo[2,3-d]pyrimidines (14-17a-c) and triazolopyrrolopyrimidines (18, 19) by reaction with different reagents . Eight compounds were selected and screened in vitro for their |
|---|---|
| ISSN: |
2523-1006 |
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