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|3 10.35778/1742-000-012-023
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|a eng
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|b ليبيا
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|9 451678
|a Musa, Suliman M.
|e Author
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|a Synthesis and Biological Activity of Some New 2-(2,4 dimethoxyphenylpyrrolo [2,3-d] Pyrimidine Compounds
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|b جامعة الزيتونة
|c 2014
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|a 66 - 79
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|a بحوث ومقالات
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|b The present work is aimed to synthesize some new heterocyclic compounds containing pyrrolo[2,3-d]pyrimidines, \ Our approach to the synthesis of the target compounds started through the hydrolysis of 6-ethylthio-4-methyl-2-(2'',4'- \ dimethoxyphenyl)pyi imidine-5-carbonitrile (2) by refluxing in ethanol containing sodium hydroxide to give the corresponding sodium salt derivative (3) which in turn wais acidified to give 5-cyano-4-niethyl-2-(2 A- dimethoxyphenyl)pyrimidin-6(H)one (4). Chlorination of the hydroxy derivative (4) afforded 6-Chloro-4-methyl-2-(2\\4'- dimethoxyphenyl)pyrimidin-5-carbonitrile (5), which reacted with ethyl glycinate hydrochloride.to give Ethyl (5-cyano-4-methyl-2-(2\\4'- dimethoxyphenyl)yrimidin-6-yloxy)acetate (6),which underwent cyclization to give the ethyl 5-amino-4-methyl-2-(2,4'-dimethoxyphenyl)-7H- pyrrolo[2,3-d]pyrimidine-6-carboxylate (10). Also the reaction of compound (5) with piperidine, and morpholine, gave the piperidino- and morphilino- derivatives (7) and (8) respectively. \ The compound (10) was used as key intermediates in the synthesis of other new pyrrolo[2,3-d]pyrimidine derivatives (11-13), pyrimido[4\\5\\4,5]pyrrolo[2,3-d]pyrimidines (14-17a-c) and triazolopyrrolopyrimidines (18, 19) by reaction with different reagents . Eight compounds were selected and screened in vitro for their
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|a الكيمياء الحيوية
|a القواعد النيتروجينية
|a المضادات الحيوية
|a التجارب العملية
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| 773 |
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|4 العلوم الإنسانية ، متعددة التخصصات
|4 العلوم الاجتماعية ، متعددة التخصصات
|6 Humanities, Multidisciplinary
|6 Social Sciences, Interdisciplinary
|c 023
|e Azzaytuna University Journal
|f Mağallaẗ ğāmiʿaẗ al-Zaytūnaẗ
|l 012
|m ع12
|o 1742
|s مجلة جامعة الزيتونة
|v 000
|x 2523-1006
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| 856 |
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|u 1742-000-012-023.pdf
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| 930 |
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|d y
|p y
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|a EcoLink
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|a EduSearch
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|a IslamicInfo
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| 995 |
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|a HumanIndex
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|c 840427
|d 840427
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