| المستخلص: |
Background: Pregnancy is a natural physiological changes that is accompanied with harmonic and metabolic alterations caused by a variety of conditions that results in many pathophysiologic processes, some of which have potentially serious outcomes if left untreated. Thyroid diseases during pregnancy are related to maternal and fetal complications. Aim: The aim of this study is to evaluate the thyroid hormones levels in Sudanese pregnant women. Materials and Methods: This study was performed in Teanbool hospital in Aljazeera state during the period from February to July 2017. 50 samples were collected from pregnant women (28% in first, 34% in second and 38% in third) as study group. In addition to other 50 non-pregnant healthy women and age matched as control group. The thyroid hormones TSH, FT3 and FT4 levels in both test and control group, were estimated by automated Cobas e 411 analyzer using electro chemiluminescence immunoassay “ECLIA” Result: decrease in all thyroid hormones in pregnant woman, also there have only significant decreased in FT4 in case (12.77±2.54) compare with control (14.80±1.95) P-value 0.000. Significant decreased showed in FT3 in second trimester (4.16±0.59) and FT4 in second (11.76±1.65) and third (11.28±1.68) trimesters when compared it with mean of control (P-value 0.045, 0.000 & 0.000) respectively. significant decreased in FT3 in second trimester (4.16±0.59) (P-value 0.006) and in FT4 in second (4.16±0.59) and third (11.28±1.68) trimesters (P-value 0.000 and 0.000) respectively When compared different trimesters together. conclusion, generally decrease in FT3, FT4 and TSH but significantly decrease in FT4 level among pregnant women compare with non-pregnant. Significant decreased in FT3 in second trimester and FT4 in second and third trimesters when compared with non-pregnant. Significant decreased in FT3 in second trimester and in FT4 in second and third trimesters when compare between different trimesters. Conclusion: The study revealed significant decrease in both fT3 and fT4 associated with slight increases of TSH level in the pregnant women.
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