المستخلص: |
ESBL producing Gram Negative bacteria have emerged as a major threat worldwide as they produce the enzyme Beta-lactamase which hydrolyse betalactam antibiotics containing an oxyimino group (Third generation cephalosporin s and aztreonam) and are inhibited by -lactamase inhibitors such as clavulanic acid, sulbactam and tazobactam. A total of 32 isolates from diabetic foot wounds of patients attended to outpatient clinics in the central hospital of Misurata city over a period of 3 months were included in the study. Bacterial species were identified by using standard microbiological culture and biochemical reactions, while screening and double-disc synergy confirmatory tests were used to detect ESBLs production. This study finding showed Pseudomonas aeruginosa (p. aeruginosa) was the dominant gram negative bacterial species (11/32) isolated from diabetic foot wounds. Moreover, study results reveal low prevalence of ESBLs producing isolates among included bacterial collection (1/32; 3%) whereas, positive isolate was identified as p. aeruginosa.
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