Mechanistic Studies on Aziridinyl-Benzoquinones in Cultured Tumour Cells
| المصدر: | مجلة القلعة |
|---|---|
| الناشر: | جامعة المرقب - كلية الآداب والعلوم بمسلاته |
| المؤلف الرئيسي: | Ben Rabha, Fatma M. (Author) |
| مؤلفين آخرين: | Elashheb, Mabruka S. (Co-Author) , Saeed, Nagat M. (Co-Author) , Hassan, Samia Abd Alkarim Ali (Co-Author) , Ben Saad, Lamees A. (Co-Author) |
| المجلد/العدد: | ع7 |
| محكمة: | نعم |
| الدولة: |
ليبيا |
| التاريخ الميلادي: |
2017
|
| الشهر: | يونيو |
| الصفحات: | 690 - 712 |
| رقم MD: | 891630 |
| نوع المحتوى: | بحوث ومقالات |
| اللغة: | الإنجليزية |
| قواعد المعلومات: | HumanIndex |
| مواضيع: | |
| رابط المحتوى: |
عدد مرات التحميل
2
| LEADER | 01976nam a22002537a 4500 | ||
|---|---|---|---|
| 001 | 1641499 | ||
| 041 | |a eng | ||
| 044 | |b ليبيا | ||
| 100 | |9 478684 |a Ben Rabha, Fatma M. |e Author | ||
| 245 | |a Mechanistic Studies on Aziridinyl-Benzoquinones in Cultured Tumour Cells | ||
| 260 | |b جامعة المرقب - كلية الآداب والعلوم بمسلاته |c 2017 |g يونيو | ||
| 300 | |a 690 - 712 | ||
| 336 | |a بحوث ومقالات |b Article | ||
| 520 | |b This study compares the anti tumour effects of the novel NQO1 activated drug RH1 (2, 5-diaziridinyl-3 -hydoxymethyl-6-methyl-1, 4- benzoquinone) with a novel lipophilic ester derivative Es5 on the isogenic cell lines MDA 468 and MDA 468 NQO1 which differs only in expression of wtNQO1. A 39- fold enhancement of growth inhibitory activity was seen in NQO1 expressing cells compared the NQO1 null cells for the Es5 compared to the 25- fold increase seen for the parent drug, RH1. The kinetics of cell cycle arrest, apoptosis are different in the NQO1 expressing and null cell lines. This indicates a different mechanism of activations and/ or activity for these agents in the presence of active NQO1 protein. We show that Es5 has a higher partition coefficient than RH1, which may enable Es5 to enter the brain. Following cleavage of the ester group Es5 produces a Quinone whose cytoxicity profile is comparable to RH1. | ||
| 653 | |a زراعة الأورام |a الأدوية المنشطة |a خلايا الأورام | ||
| 700 | |9 478685 |a Elashheb, Mabruka S. |e Co-Author | ||
| 700 | |9 711066 |a Saeed, Nagat M. |e Co-Author | ||
| 700 | |9 33453 |a Hassan, Samia Abd Alkarim Ali |e Co-Author | ||
| 700 | |9 711067 |a Ben Saad, Lamees A. |e Co-Author | ||
| 773 | |4 العلوم الإنسانية ، متعددة التخصصات |6 Humanities, Multidisciplinary |c 027 |e Alqala Journal |l 007 |m ع7 |o 1878 |s مجلة القلعة |v 000 | ||
| 856 | |u 1878-000-007-027.pdf | ||
| 930 | |d y |p y | ||
| 995 | |a HumanIndex | ||
| 999 | |c 891630 |d 891630 | ||
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