المستخلص: |
This study was conducted to assess the chemical composition of two Sudanese wild Medicinal Plants used in the traditional medicine for the wide range of ailments and to evaluate their antimicrobial activity. The petroleum ether and methanol + water (80:20) extracts of aerial parts of Guiera senegalensis and Solenostemma argel leaves at different concentrations (10, 25 and 50%) were tested against six types of bacteria (Bacillus subtilis, Staphylococcus aureus, Escherichia coli, Klebsiella pneumonae, Proteus vulgaris and Pseudomonas aeruginosa) and two fungi (Aspergellus niger and Candida albicans), using the agar- well diffusion method. The results of petroleum ether and methanol extracts of Guiera senegalensis showed a broad spectrum of antimicrobial activity. Good activity was exhibited by the Petroleum ether extract of S. argel which significantly active against E. coli and S. aureus. The results of plants compared with standard antibiotics found that the antibacterial drug is less active than the plants extracts, while the antifungal drugs are more active than the plants extracts. The results showed that the two plants contain: Alkaloids, cardiac glycoside, saponins, sterols, triterpenes and coumarins as major secondary metabolites. Study concluded that the bacterial species tested were found to be sensitive to petroleum ether and methanol+ water extracts from aerial parts of G. senegalensis in all different concentrations with diameter of inhibition zone ranged from (10-31mm) but there was very effective bactericidal in high concentrations. The plant contained variety of different chemical compositions.
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