The Role of the Peroxisome Proliferator Activated Gamma Receptor (PPAR-γ) In Reducing of Neurodegenerative Disorders
| المصدر: | المجلة الجامعة |
|---|---|
| الناشر: | جامعة الزاوية - مركز البحوث والدراسات العليا |
| المؤلف الرئيسي: | Abushofa, Fikry A. (Author) |
| المجلد/العدد: | مج18, ع1 |
| محكمة: | نعم |
| الدولة: |
ليبيا |
| التاريخ الميلادي: |
2016
|
| الشهر: | يناير |
| الصفحات: | 194 - 226 |
| رقم MD: | 1263363 |
| نوع المحتوى: | بحوث ومقالات |
| اللغة: | الإنجليزية |
| قواعد المعلومات: | EduSearch, EcoLink, IslamicInfo, AraBase, HumanIndex |
| مواضيع: | |
| كلمات المؤلف المفتاحية: |
PPAR-Γ Agonist | Astrocytes | Neurodegenerative Disorder | Cortex | Hippocampus
|
| رابط المحتوى: |
الناشر لهذه المادة لم يسمح بإتاحتها. |
| المستخلص: |
The peroxisome proliferator activated gamma receptor (PPAR- γ) has been shown to be involved in immune differentiation as well as playing a key role in the immune response during the inhibition of the inflammatory response. Neurodegenerative diseases including Parkinson's, Alzheimer' s, and Huntington's occur as a result of neurodegenerative changes. This study aims to shed some light on the process of astrocyte proliferation, also explain the specific role of astrocytes in the inflammatory response as well as to attempt to reverse any detrimental changes. The main goal is to follow the evolution of pathology using organotypic slices culture technique, and then try to improve or reduce the disease using PPAR- γ agonist. The results on the effect of PPAR- γ agonist and rosiglitazone, after a week of treatment, showed that the PPAR- γ agonist inhibited astrocytes activation in both the cortex and hippocampus of the mutant mice organotypic slice culture. Therefore, PPAR activation has beneficial effects in many pre-clinical models of neurodegenerative diseases and CNS injury. |
|---|
عناصر مشابهة
-
Resazurinreagent to Determine the Safe Dose of PPAR-γ Agonist for Reducing Activated Gliosis Using 3T3 Cells
بواسطة: Abushofa, Fikry A. منشور: (2016) -
The Induction of Liver Growth by Peroxisome Proliferators
بواسطة: Al Kholaifi, Abd Allah M. منشور: (2008) -
A Study on the Association of Peroxisome Proliferator Activated receptor (PPAR) y2 Gene Polymorphism with Type 2 Diabetes Mellitus
بواسطة: Al-Mahruqy, Samira Hamed منشور: (2004) -
Mechanism of Action of Liver Growth Induced by Nongenotoxic Carcinogens: Peroxisome Proliferators
بواسطة: Abushofa, Fikry A. منشور: (2015) -
Effect of olive oil, corn oil and sheep tallow on serum levels of glucose, insulin and leptin and adipose tissue peroxisome proliferator-activated receptor gamma in rats fed fructose-based diets
بواسطة: Al Jada, Doaa Nader منشور: (2011)
