The Role of the Peroxisome Proliferator Activated Gamma Receptor (PPAR-γ) In Reducing of Neurodegenerative Disorders
| المصدر: | المجلة الجامعة |
|---|---|
| الناشر: | جامعة الزاوية - مركز البحوث والدراسات العليا |
| المؤلف الرئيسي: | Abushofa, Fikry A. (Author) |
| المجلد/العدد: | مج18, ع1 |
| محكمة: | نعم |
| الدولة: |
ليبيا |
| التاريخ الميلادي: |
2016
|
| الشهر: | يناير |
| الصفحات: | 194 - 226 |
| رقم MD: | 1263363 |
| نوع المحتوى: | بحوث ومقالات |
| اللغة: | الإنجليزية |
| قواعد المعلومات: | EduSearch, EcoLink, IslamicInfo, AraBase, HumanIndex |
| مواضيع: | |
| كلمات المؤلف المفتاحية: |
PPAR-Γ Agonist | Astrocytes | Neurodegenerative Disorder | Cortex | Hippocampus
|
| رابط المحتوى: |
الناشر لهذه المادة لم يسمح بإتاحتها. |
| المستخلص: |
The peroxisome proliferator activated gamma receptor (PPAR- γ) has been shown to be involved in immune differentiation as well as playing a key role in the immune response during the inhibition of the inflammatory response. Neurodegenerative diseases including Parkinson's, Alzheimer' s, and Huntington's occur as a result of neurodegenerative changes. This study aims to shed some light on the process of astrocyte proliferation, also explain the specific role of astrocytes in the inflammatory response as well as to attempt to reverse any detrimental changes. The main goal is to follow the evolution of pathology using organotypic slices culture technique, and then try to improve or reduce the disease using PPAR- γ agonist. The results on the effect of PPAR- γ agonist and rosiglitazone, after a week of treatment, showed that the PPAR- γ agonist inhibited astrocytes activation in both the cortex and hippocampus of the mutant mice organotypic slice culture. Therefore, PPAR activation has beneficial effects in many pre-clinical models of neurodegenerative diseases and CNS injury. |
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