Histological Study and Chemical Composition of Apium Graveolens in Vivo Antimicrobial Activity
| المصدر: | المجلة العلمية لجامعة الملك فيصل - العلوم الأساسية والتطبيقية |
|---|---|
| الناشر: | جامعة الملك فيصل |
| المؤلف الرئيسي: | Abdelsadok, Imane (Author) |
| مؤلفين آخرين: | Ouldyerou, Karima (Co-Author) , Boumediene, Meddah (Co-Author) , Sonnet, Pascal (Co-Author) |
| المجلد/العدد: | مج25, ع2 |
| محكمة: | نعم |
| الدولة: |
السعودية |
| التاريخ الميلادي: |
2024
|
| التاريخ الهجري: | 1445 |
| الصفحات: | 36 - 41 |
| ISSN: |
1658-0311 |
| رقم MD: | 1524372 |
| نوع المحتوى: | بحوث ومقالات |
| اللغة: | الإنجليزية |
| قواعد المعلومات: | science |
| مواضيع: | |
| كلمات المؤلف المفتاحية: |
Anatomopathology | Celery | Chemical Compounds | Enteric Infection | HPLC | Rats
|
| رابط المحتوى: |
| المستخلص: |
The purpose of the current investigation is to evaluate the methanolic extract from Apium graveolens seeds for chemical composition and in vivo antimicrobial activity, supported by a histological study. The chemical profile of the methanolic extract was identified using high-performance liquid chromatography diode array detector analysis. The toxicity and antimicrobial effects of the methanolic extract were examined through in vivo experiments on rats weighing 220 ± 5 g. The histological study was conducted using the rats’ ileum. The methanolic extract (80%) contained sinapic acid (49.9%), ascorbic acid (25.4%), butylated hydroxyanisole acid (6.1%), and quercetin (8.2%), with a yield ratio of 11.74%. The dose of 50 mg/kg of the methanolic extract did not lead to animal lethality or toxicity symptoms. Two days after treatment, the blood cultures of all females treated with the methanolic extract at 50 mg/kg showed sterility (100%). The same result appeared on the fifth day after treatment in all males of the same group. Histopathological examination revealed normal and well-preserved architecture of the ileum in both sexes. The study concludes that the methanolic extract of Apium graveolens possesses significant antimicrobial capacity. |
|---|---|
| ISSN: |
1658-0311 |
عناصر مشابهة
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