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|a eng
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| 044 |
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|b السعودية
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|9 808494
|a Abdelsadok, Imane
|e Author
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| 245 |
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|a Histological Study and Chemical Composition of Apium Graveolens in Vivo Antimicrobial Activity
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| 260 |
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|b جامعة الملك فيصل
|c 2024
|m 1445
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| 300 |
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|a 36 - 41
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|a بحوث ومقالات
|b Article
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|b The purpose of the current investigation is to evaluate the methanolic extract from Apium graveolens seeds for chemical composition and in vivo antimicrobial activity, supported by a histological study. The chemical profile of the methanolic extract was identified using high-performance liquid chromatography diode array detector analysis. The toxicity and antimicrobial effects of the methanolic extract were examined through in vivo experiments on rats weighing 220 ± 5 g. The histological study was conducted using the rats’ ileum. The methanolic extract (80%) contained sinapic acid (49.9%), ascorbic acid (25.4%), butylated hydroxyanisole acid (6.1%), and quercetin (8.2%), with a yield ratio of 11.74%. The dose of 50 mg/kg of the methanolic extract did not lead to animal lethality or toxicity symptoms. Two days after treatment, the blood cultures of all females treated with the methanolic extract at 50 mg/kg showed sterility (100%). The same result appeared on the fifth day after treatment in all males of the same group. Histopathological examination revealed normal and well-preserved architecture of the ileum in both sexes. The study concludes that the methanolic extract of Apium graveolens possesses significant antimicrobial capacity.
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| 653 |
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|a المستخلصات النباتية
|a نبات الكرفس
|a المركبات الكيميائية
|a علم الأمراض التشريحي
|a العدوى المعوية
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| 692 |
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|b Anatomopathology
|b Celery
|b Chemical Compounds
|b Enteric Infection
|b HPLC
|b Rats
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| 700 |
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|9 808488
|a Ouldyerou, Karima
|e Co-Author
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| 700 |
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|9 808492
|a Boumediene, Meddah
|e Co-Author
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| 700 |
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|9 808498
|a Sonnet, Pascal
|e Co-Author
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| 773 |
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|c 007
|e Scientific Journal of King Faisal University - Basic and Applied Sciences
|f almajalat aleilmiat lijamieat almalik fysl. aleulum al'asasiat waltatbiqia
|l 002
|m مج25, ع2
|o 0184
|s المجلة العلمية لجامعة الملك فيصل - العلوم الأساسية والتطبيقية
|v 025
|x 1658-0311
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| 856 |
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|u 0184-025-002-007.pdf
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| 930 |
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|d y
|p y
|q n
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| 995 |
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|a science
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| 999 |
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|c 1524372
|d 1524372
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